Trial reportCirculation2008
Milrinone use is associated with postoperative atrial fibrillation after cardiac surgery.
Trial report in Circulation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00141778 (RAAS, Inflammation, and Post-operative AF), which is not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
RAAS, Inflammation, and Post-operative AF
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Prophylactic milrinone for the prevention of low cardiac output syndrome and mortality in children undergoing surgery for congenital heart disease.The Cochrane database of systematic reviews · 2015Pooled it
- The role of milrinone in children with cardiovascular compromise: review of the literature.Wiener medizinische Wochenschrift (1946) · 2011Pooled it
- Pharmacologic prophylaxis for atrial fibrillation following cardiac surgery: a systematic review.Journal of cardiothoracic surgery · 2010Pooled it
- Angiotensin-converting enzyme inhibition or mineralocorticoid receptor blockade do not affect prevalence of atrial fibrillation in patients undergoing cardiac surgery.Critical care medicine · 2012Trial
- Early postoperative statin therapy is associated with a lower incidence of acute kidney injury after cardiac surgery.Journal of cardiothoracic and vascular anesthesia · 2010Trial
- Role of beta-blockers in reducing post-operative atrial fibrillation following cardiac surgery.Bioinformation · 2025Article
- Drug-induced AF: Arrhythmogenic Mechanisms and Management Strategies.Arrhythmia & electrophysiology review · 2024Review
- Intravenous Milrinone for Cerebral Vasospasm in Subarachnoid Hemorrhage: The MILRISPASM Controlled Before-After Study.Neurocritical care · 2021Observational
- Preoperative, Multidisciplinary Clinical Optimization of Patients with Severely Depressed Left Ventricular Ejection Fraction Who Are Undergoing Coronary Artery Bypass Grafting.Cardiology and therapy · 2021Review
- Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCirculation. Genomic and precision medicine · 2021Article
- Use of Vasoactive Medications after Cardiac Surgery in the United States.Annals of the American Thoracic Society · 2021Article
- Postoperative Atrial Fibrillation Following Cardiac Surgery: From Pathogenesis to Potential Therapies.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2020Review
- Post-operative atrial fibrillation after off-pump coronary artery bypass grafting.Indian journal of thoracic and cardiovascular surgery · 2020Article
- Increased risk of atrial fibrillation among patients undergoing coronary artery bypass graft surgery while receiving nitrates and antiplatelet agents.The Journal of international medical research · 2018Article
- Study on the clinical efficacy of specific phosphodiesterase inhibitor in patients with pulmonary hypertension due to left heart disease.Experimental and therapeutic medicine · 2018Article
- Plasma Catecholamine Levels on the Morning of Surgery Predict Post-Operative Atrial Fibrillation.JACC. Clinical electrophysiology · 2017Observational
- Perioperative Inotrope Therapy and Atrial Fibrillation Following Coronary Artery Bypass Graft Surgery: Evidence of a Racial Disparity.Pharmacotherapy · 2017Article
- Variable use of amiodarone is associated with a greater risk of recurrence of atrial fibrillation in the critically ill.Critical care (London, England) · 2016Article
- Liposomal delivery of a phosphodiesterase 3 inhibitor rescues low oxygen-induced ATP release from erythrocytes of humans with type 2 diabetes.Biochemistry and biophysics reports · 2015Article
- Hypertension is associated with preamyloid oligomers in human atrium: a missing link in atrial pathophysiology?Journal of the American Heart Association · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPostoperative atrial fibrillation (AF), a frequent complication after cardiac surgery, causes morbidity and prolongs hospitalization. Inotropic drugs are commonly used perioperatively to support ventricular function. This study tested the hypothesis that the use of inotropic drugs is associated with postoperative AF. METHODS AND
resultsWe evaluated perioperative risk factors in 232 patients who underwent elective cardiac surgery. All patients were in sinus rhythm at surgery. Sixty-seven patients (28.9%) developed AF a mean of 2.9+/-2.1 days after surgery. Patients who developed AF stayed in the hospital longer (P<0.001) and were more likely to die (P=0.02). Milrinone use was associated with an increased risk of postoperative AF (58.2% versus 26.1% in nonusers; P<0.001). Older age (63.4+/-10.7 versus 56.7+/-12.3 years; P<0.001), hypertension (P=0.04), lower preoperative ejection fraction (P=0.03), mitral valve surgery (P=0.02), right ventricular dysfunction (P=0.03), and higher mean pulmonary artery pressure (27.1+/-9.3 versus 21.8+/-7.5 mm Hg; P=0.001) also were associated with postoperative AF. In multivariable logistic regression, age (P<0.001), ejection fraction (P=0.02), and milrinone use (odds ratio, 4.86; 95% confidence interval, 2.31 to 10.25; P<0.001) independently predicted postoperative AF. When only data from patients with pulmonary artery catheters were analyzed and pulmonary artery pressure was included in the model, age, milrinone use (odds ratio, 4.45; 95% confidence interval, 2.01 to 9.84; P<0.001), and higher pulmonary artery pressure (P=0.02) were associated with an increased risk of postoperative AF. Adding other potential confounders or stratifying analysis by mitral valve surgery did not change the association of milrinone use with postoperative AF.
conclusionsMilrinone use is an independent risk factor for postoperative AF after elective cardiac surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.