ArticleThe Journal of biological chemistry2008
Mycobacterium avium glycopeptidolipids require specific acetylation and methylation patterns for signaling through toll-like receptor 2.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Review
- The microbiome and gut-lung axis in nontuberculous mycobacterial pulmonary disease.PLoS pathogens · 2025Review
- Multiomics integration reveals NETosis heterogeneity and TLR2 as a prognostic biomarker in pancreatic cancer.NPJ precision oncology · 2024Article
- Proteome Profile Changes Induced by Heterologous Overexpression ofBiomolecules · 2022Article
- The Role of TLR2 in Infectious Diseases Caused by Mycobacteria: From Cell Biology to Therapeutic Target.Biology · 2022Review
- Mutation onVirulence · 2020Article
- Lectin PLL3, a Novel Monomeric Member of the Seven-Bladed β-Propeller Lectin Family.Molecules (Basel, Switzerland) · 2019Article
- Mycobacterium abscessus glycopeptidolipids inhibit macrophage apoptosis and bacterial spreading by targeting mitochondrial cyclophilin D.Cell death & disease · 2017Article
- O-Acetyl Side-Chains in Monosaccharides: Redundant NMR Spin-Couplings and Statistical Models for Acetate Ester Conformational Analysis.The journal of physical chemistry. B · 2017Article
- Inactivation of MSMEG_0412 gene drastically affects surface related properties of Mycobacterium smegmatis.BMC microbiology · 2016Article
- High-throughput transcriptomics reveals common and strain-specific responses of human macrophages to infection with Mycobacterium abscessus Smooth and Rough variants.BMC genomics · 2015Article
- Innate defects of the IL-12/IFN-γ axis in susceptibility to infections by mycobacteria and salmonella.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2014Review
- A GMC oxidoreductase homologue is required for acetylation of glycopeptidolipid in Mycobacterium smegmatis.Biochemistry · 2014Article
- Methylation--an uncommon modification of glycans.Biological chemistry · 2012Review
- Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Identification of valine- or leucine-containing glycopeptidolipids from Mycobacterium avium-intracellulare complex.Current microbiology · 2012Article
- Structure and host recognition of serotype 13 glycopeptidolipid from Mycobacterium intracellulare.Journal of bacteriology · 2011Article
- Novel rhamnosyltransferase involved in biosynthesis of serovar 4-specific glycopeptidolipid from Mycobacterium avium complex.Journal of bacteriology · 2010Article
- Mannose receptor-dependent delay in phagosome maturation by Mycobacterium avium glycopeptidolipids.Infection and immunity · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Toll-like receptors (TLRs) recognize pathogen-associated molecules and play a vital role in promoting an immune response against invading microbes. TLR2, one of the key members of the TLR family, recognizes a wide variety of microbial products, including lipoproteins and lipopeptides, from a number of pathogens. Recent studies from our laboratory indicate that glycopeptidolipids (GPLs), a major surface component of Mycobacterium avium and other non-tuberculosis mycobacteria, are ligands for TLR2. However, the molecular requirements necessary for the GPL-TLR2 interaction were not defined in this report. In the present study we isolated different GPL species from M. avium, and using mass spectrometry and NMR analyses, characterized the molecular requirements of the GPL-TLR2 interaction. Interestingly, the extent of the respective acetylation and methylation of the 6-deoxytalose and rhamnose contained within the core GPL structure dictated whether the GPL signaled through TLR2. These experiments illustrate how subtle changes in a complex TLR2 ligand can alter its affinity for this important receptor, and suggest that M. avium could potentially modify its GPL structure to limit its interaction with TLR2.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.