ArticleInfection and immunity2008
Experimental malaria infection triggers early expansion of natural killer cells.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations.Journal of immunology (Baltimore, Md. : 1950) · 2017Trial
- Immunological characterization of a VIR protein family member (VIR-14) in Plasmodium vivax-infected subjects from different epidemiological regions in Africa and South America.PLoS neglected tropical diseases · 2023Article
- Review
- Tissue macrophages and interferon-gamma signalling control blood-stageCurrent research in immunology · 2021Article
- Protective Vaccination Reshapes Hepatic Response to Blood-Stage Malaria of Genes Preferentially Expressed by NK Cells.Vaccines · 2020Article
- Contributions of natural killer cells to the immune response against Plasmodium.Malaria journal · 2019Review
- Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway.PLoS pathogens · 2018Article
- Article
- IL-18-induced expression of high-affinity IL-2R on murine NK cells is essential for NK-cell IFN-γ production during murine Plasmodium yoelii infection.European journal of immunology · 2015Article
- ChIP-PED enhances the analysis of ChIP-seq and ChIP-chip data.Bioinformatics (Oxford, England) · 2013Article
- Protective efficacy of orally administered, heat-killed Lactobacillus pentosus b240 against influenza A virus.Scientific reports · 2013Article
- Splenic red pulp macrophages produce type I interferons as early sentinels of malaria infection but are dispensable for control.PloS one · 2012Article
- Limited response of NK92 cells to Plasmodium falciparum-infected erythrocytes.Malaria journal · 2011Article
- NK cells and immune "memory".Journal of immunology (Baltimore, Md. : 1950) · 2011Review
- Article
- Gammadelta T cells but not NK cells are essential for cell-mediated immunity against Plasmodium chabaudi malaria.Infection and immunity · 2010Article
- Genome wide linkage study, using a 250K SNP map, of Plasmodium falciparum infection and mild malaria attack in a Senegalese population.PloS one · 2010Article
- Mapping of Char10, a novel malaria susceptibility locus on mouse chromosome 9.Genes and immunity · 2010Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
In order to gain a better understanding of gene expression during early malaria infection, we conducted microarray analysis of early blood responses in mice infected with erythrocytic-stage Plasmodium chabaudi. Immediately following infection, we observed coordinated and sequential waves of immune responses, with interferon-associated gene transcripts dominating by 16 h postinfection, followed by strong increases in natural killer (NK) cell-associated and major histocompatibility complex class I-related transcripts by 32 h postinfection. We showed by flow cytometry that the observed elevation in NK cell-associated transcripts was the result of a dramatic increase in the proportion of NK cells in the blood during infection. Subsequent microarray analysis of NK cells isolated from the peripheral blood of infected mice revealed a cell proliferation expression signature consistent with the observation that NK cells replicate in response to infection. Early proliferation of NK cells was directly observed in studies with adoptively transferred cells in infected mice. These data indicate that the early response to P. chabaudi infection of the blood is marked by a primary wave of interferon with a subsequent response by NK cells.
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