ArticleDevelopmental biology2008
Internalization of plasma membrane Ca2+-ATPase during Xenopus oocyte maturation.
Article in Developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Lipid Signaling During Gamete Maturation.Frontiers in cell and developmental biology · 2022Review
- Modulators of calcium signalling at fertilization.Open biology · 2020Review
- Ion Channel Function During Oocyte Maturation and Fertilization.Frontiers in cell and developmental biology · 2018Review
- Calcitox-aging counterbalanced by endogenous farnesol-like sesquiterpenoids: An undervalued evolutionarily ancient key signaling pathway.Communicative & integrative biology · 2017Article
- Xenopus Oocyte As a Model System to Study Store-Operated Ca(2+) Entry (SOCE).Frontiers in cell and developmental biology · 2016Article
- Ca(2+) homeostasis and regulation of ER Ca(2+) in mammalian oocytes/eggs.Cell calcium · 2013Review
- Ca2+ signaling during mammalian fertilization: requirements, players, and adaptations.Cold Spring Harbor perspectives in biology · 2011Review
- Article
- Ca(2+) signaling, genes and the cell cycle.Cell calcium · 2010Review
- Constitutive recycling of the store-operated Ca2+ channel Orai1 and its internalization during meiosis.The Journal of cell biology · 2010Article
- Regulation of store-operated Ca2+ entry during the cell cycle.Journal of cell science · 2010Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
A transient increase in intracellular Ca(2+) is the universal signal for egg activation at fertilization. Eggs acquire the ability to mount the specialized fertilization-specific Ca(2+) signal during oocyte maturation. The first Ca(2+) transient following sperm entry in vertebrate eggs has a slow rising phase followed by a sustained plateau. The molecular determinants of the sustained plateau are poorly understood. We have recently shown that a critical determinant of Ca(2+) signaling differentiation during oocyte maturation is internalization of the plasma membrane calcium ATPase (PMCA). PMCA internalization is representative of endocytosis of several integral membrane proteins during oocyte maturation, a requisite process for early embryogenesis. Here we investigate the mechanisms regulating PMCA internalization. To track PMCA trafficking in live cells we cloned a full-length cDNA of Xenopus PMCA1, and show that GFP-tagged PMCA traffics in a similar fashion to endogenous PMCA. Functional data show that MPF activation during oocyte maturation is required for full PMCA internalization. Pharmacological and co-localization studies argue that PMCA is internalized through a lipid raft endocytic pathway. Deletion analysis reveal a requirement for the N-terminal cytoplasmic domain for efficient internalization. Together these studies define the mechanistic requirements for PMCA internalization during oocyte maturation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.