ArticleRespiratory research2008
A multivariate analysis of serum nutrient levels and lung function.
Article in Respiratory research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- A systematic review of the role of vitamin insufficiencies and supplementation in COPD.Respiratory research · 2010Pooled it
- Change in plasma α-tocopherol associations with attenuated pulmonary function decline and with CYP4F2 missense variation.The American journal of clinical nutrition · 2022Trial
- Randomised vitamin E supplementation and risk of chronic lung disease in the Women's Health Study.Thorax · 2011Trial
- Nutritional Support of Chronic Obstructive Pulmonary Disease.Nutrients · 2025Review
- Insights into associations between Life's essential 8 and lung function from NHANES data.Scientific reports · 2025Article
- Quantification of All-Trans Retinoic Acid and Cytokine Levels After Fungal, Viral and Bacterial Infections in the Lung.Journal of cellular and molecular medicine · 2025Article
- L-shaped association between serum chloride levels with 90-day and 365-day all-cause mortality in critically ill patients with COPD: a retrospective cohort study.Scientific reports · 2024Article
- Dietary patterns and micronutrients in respiratory infections including COVID-19: a narrative review.BMC public health · 2024Review
- Association Between Dietary Selenium Intake and Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study from the National Health and Nutrition Examination Survey 1999-2018.International journal of chronic obstructive pulmonary disease · 2024Article
- The Six Pillars of Lifestyle Medicine in Managing Noncommunicable Diseases - The Gaps in Current Guidelines.Arquivos brasileiros de cardiologia · 2024Article
- Unravelling the Therapeutic Potential of Nano-Delivered Functional Foods in Chronic Respiratory Diseases.Nutrients · 2022Review
- Long-term exposure to air pollution and lung function among children in China: Association and effect modification.Frontiers in public health · 2022Article
- Dysregulated retinoic acid signaling in airway smooth muscle cells in asthma.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Comprehensive review of lipocalin 2-mediated effects in lung inflammation.American journal of physiology. Lung cellular and molecular physiology · 2021Review
- Tocotrienols: Dietary Supplements for Chronic Obstructive Pulmonary Disease.Antioxidants (Basel, Switzerland) · 2021Review
- Lung function decline is associated with serum uric acid in Korean health screening individuals.Scientific reports · 2021Article
- Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease.Respiratory research · 2021Review
- Hypertension and Electrolyte Disorders in Patients with COVID-19.Electrolyte & blood pressure : E & BP · 2020Review
- Risk Factors Associated With Long-Term Hospitalization in Patients With COVID-19: A Single-Centered, Retrospective Study.Frontiers in medicine · 2020Article
- Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundThere is mounting evidence that estimates of intakes of a range of dietary nutrients are related to both lung function level and rate of decline, but far less evidence on the relation between lung function and objective measures of serum levels of individual nutrients. The aim of this study was to conduct a comprehensive examination of the independent associations of a wide range of serum markers of nutritional status with lung function, measured as the one-second forced expiratory volume (FEV1).
methodsUsing data from the Third National Health and Nutrition Examination Survey, a US population-based cross-sectional study, we investigated the relation between 21 serum markers of potentially relevant nutrients and FEV1, with adjustment for potential confounding factors. Systematic approaches were used to guide the analysis.
resultsIn a mutually adjusted model, higher serum levels of antioxidant vitamins (vitamin A, beta-cryptoxanthin, vitamin C, vitamin E), selenium, normalized calcium, chloride, and iron were independently associated with higher levels of FEV1. Higher concentrations of potassium and sodium were associated with lower FEV1.
conclusionMaintaining higher serum concentrations of dietary antioxidant vitamins and selenium is potentially beneficial to lung health. In addition other novel associations found in this study merit further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.