Evidence map›Paper›PMID 18822388›Full record

ReviewCurrent opinion in microbiology2008

Virogenomics: the virus-host interaction revisited.

Arno C Andeweg, Bart L Haagmans, Albert Dme Osterhaus

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Arno C AndewegDepartment of Virology, Erasmus Medical Center, Rotterdam, The Netherlands. a.andeweg@erasmusmc.nl
Bart L Haagmans
Albert Dme Osterhaus

Funding

Macaque Model and Gene Expression Profiling of SARSR01HL080621 · NHLBI · UNIVERSITY OF WASHINGTON · PI KATZE, MICHAEL G · 2006 to 2009
$2.5M
NHLBI NIH HHS R01 HL080621NHLBI NIH HHS R01 HL080621-O1A1
6 · The paper itself

Abstract

Genomics tools allow us to assess gene expression 'genome wide' providing an unprecedented view on the host-side of the virus-host interaction. The success of the application of these tools crucially depends on our ability to reduce the total information load while increasing the information density of the data collected. In addition to the advanced data analysis algorithms, gene annotation-pathway databases, and theoretical models, specifically designed sets of complementary experiments are crucial in translating the collected genomics data into palatable knowledge. A better understanding of the molecular basis of virus-host interactions will support the rational design of improved and novel intervention strategies for viral infections.

Indexed as

Gene Expression ProfilingHost-Pathogen InteractionsGene Expression RegulationGene Expression Regulation, ViralViruses

Identifiers

PMID18822388
PMCPMC7108363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.