ArticleBMC neuroscience2008
Bioinformatic and statistical analysis of the optic nerve head in a primate model of ocular hypertension.
Article in BMC neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 55 citations in OpenAlex.
- Bridging Hypoxia and Vision Loss: The Emerging Role of Connexins in Local and Systemic Eye Diseases.International journal of molecular sciences · 2026Review
- Emerging strategies targeting genes and cells in glaucoma.Vision research · 2025Review
- Optic Nerve Head Gene Transcription Sequelae to a Single Elevated IOP Exposure Provides Insights Into Known Responses to Chronically Elevated IOP.Investigative ophthalmology & visual science · 2023Article
- Decorin-An Antagonist of TGF-β in Astrocytes of the Optic Nerve.International journal of molecular sciences · 2021Article
- Early Functional Impairment in Experimental Glaucoma Is Accompanied by Disruption of the GABAergic System and Inceptive Neuroinflammation.International journal of molecular sciences · 2021Article
- Article
- Neuroinflammatory Mechanisms of Mitochondrial Dysfunction and Neurodegeneration in Glaucoma.Journal of ophthalmology · 2021Review
- Sub-region-Specific Optic Nerve Head Glial Activation in Glaucoma.Molecular neurobiology · 2020Article
- Article
- T-Lymphocyte Subset Distribution and Activity in Patients With Glaucoma.Investigative ophthalmology & visual science · 2019Article
- Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis.Progress in retinal and eye research · 2017Review
- A Period of Controlled Elevation of IOP (CEI) Produces the Specific Gene Expression Responses and Focal Injury Pattern of Experimental Rat Glaucoma.Investigative ophthalmology & visual science · 2016Article
- Integrative properties of retinal ganglion cell electrical responsiveness depend on neurotrophic support and genotype in the mouse.Experimental eye research · 2016Article
- The non-human primate experimental glaucoma model.Experimental eye research · 2015Article
- Modeling glaucoma in rats by sclerosing aqueous outflow pathways to elevate intraocular pressure.Experimental eye research · 2015Review
- Bioinformatics analysis to identify the differentially expressed genes of glaucoma.Molecular medicine reports · 2015Article
- Bioinformatics analysis of potential essential genes that response to the high intraocular pressure on astrocyte due to glaucoma.International journal of ophthalmology · 2015Article
- The complex role of neuroinflammation in glaucoma.Cold Spring Harbor perspectives in medicine · 2014Review
- Differential gene expression in glaucoma.Cold Spring Harbor perspectives in medicine · 2014Review
- Intrinsic axonal degeneration pathways are critical for glaucomatous damage.Experimental neurology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe nonhuman primate model of glaucomatous optic neuropathy most faithfully reproduces the human disease. We used high-density oligonucleotide arrays to investigate whole genome transcriptional changes occurring at the optic nerve head during primate experimental glaucoma.
resultsLaser scarification of the trabecular meshwork of cynomolgus macaques produced elevated intraocular pressure that was monitored over time and led to varying degrees of damage in different samples. The macaques were examined clinically before enucleation and the myelinated optic nerves were processed post-mortem to determine the degree of neuronal loss. Global gene expression was examined in dissected optic nerve heads with Affymetrix GeneChip microarrays. We validated a subset of differentially expressed genes using qRT-PCR, immunohistochemistry, and immuno-enriched astrocytes from healthy and glaucomatous human donors. These genes have previously defined roles in axonal outgrowth, immune response, cell motility, neuroprotection, and extracellular matrix remodeling.
conclusionOur findings show that glaucoma is associated with increased expression of genes that mediate axonal outgrowth, immune response, cell motility, neuroprotection, and ECM remodeling. These studies also reveal that, as glaucoma progresses, retinal ganglion cell axons may make a regenerative attempt to restore lost nerve cell contact.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.