ArticleClinical and experimental immunology2008
Higher constitutive IL15R alpha expression and lower IL-15 response threshold in coeliac disease patients.
Article in Clinical and experimental immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 71 citations in OpenAlex.
- Innate immune dysregulation in celiac disease and refractory celiac disease: mechanisms, management and emerging therapies.Frontiers in immunology · 2026Review
- Interleukin-15 gene polymorphism in children with celiac disease: a single-center experience.European journal of pediatrics · 2025Article
- New Insights on Genes, Gluten, and Immunopathogenesis of Celiac Disease.Gastroenterology · 2024Review
- Pivotal Role of Inflammation in Celiac Disease.International journal of molecular sciences · 2022Review
- Inflammation Is Present, Persistent and More Sensitive to Proinflammatory Triggers in Celiac Disease Enterocytes.International journal of molecular sciences · 2022Article
- The Predictive Value of Serum Cytokines for Distinguishing Celiac Disease from Non-Celiac Gluten Sensitivity and Healthy SubjectsIranian biomedical journal · 2020Article
- Evaluation of expression of common genes in the intestine and peripheral blood mononuclear cells (PBMC) associated with celiac disease.Gastroenterology and hepatology from bed to bench · 2020Article
- Constitutive alterations in vesicular trafficking increase the sensitivity of cells from celiac disease patients to gliadin.Communications biology · 2019Article
- Immunogenetic Pathogenesis of Celiac Disease and Non-celiac Gluten Sensitivity.Current gastroenterology reports · 2016Review
- Current Status of Celiac Disease Drug Development.The American journal of gastroenterology · 2016Review
- Elderly Onset Celiac Disease: A Narrative Review.Clinical medicine insights. Gastroenterology · 2016Review
- Celiac disease: role of intestinal compartments in the mucosal immune response.Molecular and cellular biochemistry · 2016Article
- Effector and suppressor T cells in celiac disease.World journal of gastroenterology · 2015Review
- Human colon-derived soluble factors modulate gut microbiota composition.Frontiers in oncology · 2015Article
- Lessons from rodent models in celiac disease.Mucosal immunology · 2015Review
- Gliadin peptides as triggers of the proliferative and stress/innate immune response of the celiac small intestinal mucosa.International journal of molecular sciences · 2014Review
- Modeling of celiac disease immune response and the therapeutic effect of potential drugs.BMC systems biology · 2013Article
- Differential IL-13 production by small intestinal leukocytes in active coeliac disease versus refractory coeliac disease.Mediators of inflammation · 2013Article
- Broad MICA/B expression in the small bowel mucosa: a link between cellular stress and celiac disease.PloS one · 2013Article
- Celiac disease: prevalence, diagnosis, pathogenesis and treatment.World journal of gastroenterology · 2012Review
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The IL-15 triggering effect of gliadin is not exclusive to coeliac disease (CD) patients, whereas the secondary response is CD specific. We have studied the expression of the IL-15 receptor, and the IL-15 response upon stimulation, in non-CD and CD patients, and the possible existence of a lower immunological threshold in the latter. Forty-two CD patients (20 on a gluten-containing diet, GCD, and 22 on gluten-free diet, GFD) and 24 non-CD healthy individuals were studied. IL15R alpha mRNA expression, and tissue characterization, were assayed in the duodenum. Biopsies from six CD patients on GFD and 10 non-CD individuals were studied in vitro using organ culture in basal conditions, as well as after IL-15 stimulation discarding basal IL-15 production. Secretion of immune mediators was measured in the culture supernatants. IL15R alpha mRNA expression was increased in CD patients, as compared with non-CD controls (on GFD P = 0.0334, on GCD P = 0.0062, respectively), and confirmed also by immunofluorescence. No differences were found between CD patients on GFD and on GCD. After in vitro IL-15 stimulation, IL15R alpha expression was only triggered in non-CD controls (P = 0.0313), though it remained increased in CD patients. Moreover, IL-15 induced a more intense immunological response in CD patients after triggering the production of both nitrites and IFN gamma (P = 0.0313, P = 0.0313, respectively). Gliadin-induced IL15 has a lower response threshold in CD patients, leading to the production of other immune mediators and the development of the intestinal lesion, and thus magnifying its effects within the CD intestine.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.