ArticleGenesis (New York, N.Y. : 2000)2008
Lentiviral integration preferences in transgenic mice.
Article in Genesis (New York, N.Y. : 2000), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed.
- Prevention of aminoglycoside-induced outer hair cell loss by silencing CaMKKβ in an acute mouse model.Hearing research · 2025Article
- In vivo placental gene modulation via sonoporation.Placenta · 2025Article
- Genetically modified non-human primate models for research on neurodegenerative diseases.Zoological research · 2024Review
- The regulatory roles of microRNAs toward pathogenesis and treatments in Huntington's disease.Journal of biomedical science · 2021Review
- Implementation of CRISPR/Cas9 Genome Editing to Generate Murine Lung Cancer Models That Depict the Mutational Landscape of Human Disease.Frontiers in cell and developmental biology · 2021Article
- Massively parallel profiling and predictive modeling of the outcomes of CRISPR/Cas9-mediated double-strand break repair.Nucleic acids research · 2019Article
- Pooled library screening with multiplexed Cpf1 library.Nature communications · 2019Article
- A genome-integrated massively parallel reporter assay reveals DNA sequence determinants of cis-regulatory activity in neural cells.Nucleic acids research · 2017Article
- Generation of transgenic marmosets expressing genetically encoded calcium indicators.Scientific reports · 2016Article
- Genetic heterogeneity of induced pluripotent stem cells: results from 24 clones derived from a single C57BL/6 mouse.PloS one · 2015Article
- Pathogenic cellular phenotypes are germline transmissible in a transgenic primate model of Huntington's disease.Stem cells and development · 2013Article
- Progress and prospects for genetic modification of nonhuman primate models in biomedical research.ILAR journal · 2013Review
- Highly efficient generation of transgenic sheep by lentivirus accompanying the alteration of methylation status.PloS one · 2013Article
- Variegation and silencing in a lentiviral-based murine transgenic model.Transgenic research · 2010Article
- Rapid generation of dendritic cell specific transgenic mice by lentiviral vectors.Transgenic research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Lentiviral gene transfer has a significant impact on the development of biomedical research. One of the most important features of lentiviruses is the capability to infect both dividing and nondividing cells. However, little is known whether integration preference exists, specifically in early embryos. An in-depth genome analysis on 112 independent lentiviral integration sites from 43 transgenic founder mice was performed to determine if there are preferable sites for lentiviral integration in early embryonic genome. Our results demonstrated that lentiviruses were biased in integrating within intragenic regions, especially in the introns. However, no integration preference was found associated with specific chromosomes, repetitive elements, or CpG islands, nor was there any preference for integrating at close proximity to transcription start sites. Our findings suggested that lentiviruses were biased to integrate into the intragenic regions of early embryonic genome of mouse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.