ArticleJournal of cellular physiology2009
BAG3 protein regulates caspase-3 activation in HIV-1-infected human primary microglial cells.
Article in Journal of cellular physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Autophagy induced by human adenovirus B7 structural protein VI inhibits viral replication.Virologica Sinica · 2023Article
- Lamin B is a target for selective nuclear PQC by BAG3: implication for nuclear envelopathies.Cell death & disease · 2019Article
- The Multifunctional Protein BAG3: A Novel Therapeutic Target in Cardiovascular Disease.JACC. Basic to translational science · 2018Article
- HIV-1 Tat increases BAG3 via NF-κB signaling to induce autophagy during HIV-associated neurocognitive disorder.Cell cycle (Georgetown, Tex.) · 2018Article
- In vitro modeling of HIV proviral activity in microglia.The FEBS journal · 2017Article
- Plasmacytoid dendritic cells appear inactive during sub-microscopic Plasmodium falciparum blood-stage infection, yet retain their ability to respond to TLR stimulation.Scientific reports · 2017Article
- Review
- Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress.PLoS pathogens · 2017Article
- High expression of BAG3 predicts a poor prognosis in human medulloblastoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes.Journal of molecular and cellular cardiology · 2016Article
- BAG3 elevation inhibits cell proliferation via direct interaction with G6PD in hepatocellular carcinomas.Oncotarget · 2016Article
- Cardiac Dysfunction in HIV-1 Transgenic Mouse: Role of Stress and BAG3.Clinical and translational science · 2015Article
- WW domain of BAG3 is required for the induction of autophagy in glioma cells.Journal of cellular physiology · 2015Article
- BAG3 down-modulation sensitizes HPV18(+) HeLa cells to PEITC-induced apoptosis and restores p53.Cancer letters · 2014Article
- HIV-1 Tat protein induces glial cell autophagy through enhancement of BAG3 protein levels.Cell cycle (Georgetown, Tex.) · 2014Article
- BAG3 protects bovine papillomavirus type 1-transformed equine fibroblasts against pro-death signals.Veterinary research · 2013Article
- Chaperone-assisted proteostasis is essential for mechanotransduction in mammalian cells.Communicative & integrative biology · 2013Article
- BAG3-dependent noncanonical autophagy induced by proteasome inhibition in HepG2 cells.Autophagy · 2013Article
- Article
- BAG3: a multifaceted protein that regulates major cell pathways.Cell death & disease · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
BAG3, a member of the BAG co-chaperones family, is expressed in several cell types subjected to stressful conditions, such as exposure to high temperature, heavy metals, drugs. Furthermore, it is constitutively expressed in some tumors. Among the biological activities of the protein, there is apoptosis downmodulation; this appears to be exerted through BAG3 interaction with the heat shock protein (Hsp) 70, that influences cell apoptosis at several levels. We recently reported that BAG3 protein was detectable in the cytoplasm of reactive astrocytes in HIV-1-associated encephalopathy biopsies. Here we report that downmodulation of BAG3 protein levels allows caspase-3 activation by HIV-1 infection in human primary microglial cells. This is the first reported evidence of a role for BAG3 in the balance of death versus survival during viral infection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.