ReviewJournal of neurology2008
Dopamine dysregulation syndrome. Hypothetical application of reward system stimulation for the treatment of anhedonia in Parkinson's disease patients.
Review in Journal of neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Chronic Systemic Inflammation Exacerbates Neurotoxicity in a Parkinson's Disease Model.Oxidative medicine and cellular longevity · 2020Article
- MPPMolecular neurobiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The management of motor symptoms in Parkinson's disease (PD), although imperfect, has already been standardized. However, patients often spend their time idly despite improvement in the elemental motor symptoms. The main cause of this may be anhedonia. Dopamine dysregulation syndrome (DDS) is a troublesome condition that can occur as a complication of dopamine replacement therapy in PD. As anhedonia and DDS may be converse syndromes in PD patients, it is very important to overcome anhedonia to improve patients' quality of life. In this article, the author proposes the possibility of stimulating patients' desire to participate in physical activity via the incentive of a reward system. Understanding the mechanism of DDS may help in the development of this type of approach.
Indexed as
Identifiers
18821081What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.