ArticlePLoS neglected tropical diseases2008
Evidence for positive selection in putative virulence factors within the Paracoccidioides brasiliensis species complex.
Article in PLoS neglected tropical diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- PbGP43 Genotyping Using Paraffin-Embedded Biopsies of Human Paracoccidioidomycosis Reveals a Genetically Distinct Lineage in the Paracoccidioides brasiliensis Complex.Mycopathologia · 2022Article
- An Indian lineage of Histoplasma with strong signatures of differentiation and selection.Fungal genetics and biology : FG & B · 2022Article
- Molecular epidemiology of Paracoccidiodes spp. recovered from patients with paracoccidioidomycosis in a teaching hospital from Minas Gerais State of Brazil.PLoS neglected tropical diseases · 2021Article
- Serotype-specific evolutionary patterns of antimicrobial-resistant Salmonella enterica.BMC evolutionary biology · 2019Article
- Genetic Diversity Studies Based on Morphological Variability, Pathogenicity and Molecular Phylogeny of theFrontiers in microbiology · 2018Article
- Species boundaries in the human pathogen Paracoccidioides.Fungal genetics and biology : FG & B · 2017Article
- The extraordinary variation of the organellar genomes of the Aneura pinguis revealed advanced cryptic speciation of the early land plants.Scientific reports · 2017Article
- Genetic Stability and Evolution of theApplied and environmental microbiology · 2017Article
- Review
- Molecular phylogeny, pathogenicity and toxigenicity of Fusarium oxysporum f. sp. lycopersici.Scientific reports · 2016Article
- Cryptic species of Paracoccidioides brasiliensis: impact on paracoccidioidomycosis immunodiagnosis.Memorias do Instituto Oswaldo Cruz · 2013Article
- Epidemiology of Invasive Fungal Infections in Latin America.Current fungal infection reports · 2012Article
- Paracoccidioidomycosis in a dog: case report of generalized lymphadenomegaly.Mycopathologia · 2011Article
- Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Paracoccidioides brasiliensis is a dimorphic fungus that is the causative agent of paracoccidioidomycosis, the most important prevalent systemic mycosis in Latin America. Recently, the existence of three genetically isolated groups in P. brasiliensis was demonstrated, enabling comparative studies of molecular evolution among P. brasiliensis lineages. Thirty-two gene sequences coding for putative virulence factors were analyzed to determine whether they were under positive selection. Our maximum likelihood-based approach yielded evidence for selection in 12 genes that are involved in different cellular processes. An in-depth analysis of four of these genes showed them to be either antigenic or involved in pathogenesis. Here, we present evidence indicating that several replacement mutations in gp43 are under positive balancing selection. The other three genes (fks, cdc42 and p27) show very little variation among the P. brasiliensis lineages and appear to be under positive directional selection. Our results are consistent with the more general observations that selective constraints are variable across the genome, and that even in the genes under positive selection, only a few sites are altered. We present our results within an evolutionary framework that may be applicable for studying adaptation and pathogenesis in P. brasiliensis and other pathogenic fungi.
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