Evidence map›Paper›PMID 18820695›Full record

ArticleNature neuroscience2008

Questioning the role of rebound firing in the cerebellum.

Karina Alviña, Joy T Walter, Adam Kohn, Graham Ellis-Davies, Kamran Khodakhah

Abstract read
In one paragraph

Article in Nature neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Differential Coding Strategies in Glutamatergic and GABAergic Neurons in the Medial Cerebellar Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  12. Article
  13. Article
  14. Article
  15. Long-Lasting Response Changes in Deep Cerebellar NucleiFrontiers in cellular neuroscience · 2019
    Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Karina AlviñaDominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Joy T Walter
Adam Kohn
Graham Ellis-Davies
Kamran Khodakhah

Funding

PHOTOCHEMICAL REGULATION OF CALCIUM IN CELL PHYSIOLOGYR01GM053395 · NIGMS · OREGON HEALTH AND SCIENCE UNIVERSITY · PI ELLIS-DAVIES, GRAHAM · 1995 to 2020
$6.1M
Cerebellar Function in Health and DiseaseR01NS050808 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KHODAKHAH, KAMRAN · 2006 to 2016
$3.9M
Central synapse function studies with 2-photon uncagingR24GM065473 · NIGMS · DREXEL UNIVERSITY · PI ELLIS-DAVIES, GRAHAM · 2002 to 2005
$1.6M
Rapid-Onset Dystonia-ParkinsonismR21NS054251 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI KHODAKHAH, KAMRAN · 2006 to 2007
$408k
NIGMS NIH HHS GM53395NIGMS NIH HHS GM65473NIGMS NIH HHS R01 GM053395NIGMS NIH HHS R24 GM065473NINDS NIH HHS NS050808NINDS NIH HHS NS054251NINDS NIH HHS R01 NS050808NINDS NIH HHS R21 NS054251ONDIEH CDC HHS ND44564
6 · The paper itself

Abstract

A key component of recent theories on cerebellar function is rebound firing in neurons of the deep cerebellar nuclei (DCN). Despite the robustness of this phenomenon in vitro, in vivo studies have provided little evidence for its prevalence. We found that intact mouse or rat DCN neurons rarely showed rebound firing under physiological conditions in vitro or in vivo. These observations necessitate a critical re-evaluation of recent cerebellar models.

Indexed as

Models, NeurologicalAction PotentialsAnimalsAnimals, NewbornCerebellar NucleiElectric Stimulationgamma-Aminobutyric AcidIn Vitro TechniquesMaleMiceMice, Inbred C57BLNeural InhibitionNeuronsPatch-Clamp TechniquesRatsRats, Wistargamma-Aminobutyric Acid

Identifiers

PMID18820695
PMCPMC2691662

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.