Evidence map›Paper›PMID 18820588›Full record

ArticleThe Pediatric infectious disease journal2008

Viral respiratory infection and the link to asthma.

James E Gern

Open access · greenAbstract read
In one paragraph

Article in The Pediatric infectious disease journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 117 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. [Influenza and cardiorespiratory events: a clinical-epidemiological review with a multidisciplinary point of view].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2021
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Update on current views and advances on RSV infection (Review).International journal of molecular medicine · 2020
    Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Monitoring asthma in childhood.European respiratory review : an official journal of the European Respiratory Society · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

James E GernDivision of Pediatric Allergy, Immunology, and Rheumatology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA. gern@medicine.wisc.edu
University of Wisconsin–Madison · US

Funding

Virus-Bacterial Interactions and Exacerba of AsthmaP01HL070831 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI LEMANSKE, ROBERT F · 2002 to 2017
$31.3M
RV-Mediated Mechanisms of Neutrophil Motility /InflammatU19AI070503 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E. · 2006 to 2010
$6.8M
Rhinovirus infection of bronchial epithelium &IL-8 mRNAP01AI050500 · NIAID · UNIVERSITY OF WISCONSIN MADISON · PI GERN, JAMES E. · 2001 to 2005
$5.6M
NHLBI NIH HHS P01 HL070831NHLBI NIH HHS P01HL070831NIAID NIH HHS P01 AI050500NIAID NIH HHS P01 AI50500NIAID NIH HHS U19 AI070503
6 · The paper itself

Abstract

Viral respiratory infections are closely associated with wheezing illnesses and exacerbations of asthma throughout childhood, and yet there are a number of remaining questions pertaining to the specific nature of this relationship. Infection with an expanding list of respiratory viruses is an important cause of acute wheezing in infancy, and viruses are detected in most exacerbations of asthma throughout childhood. Furthermore, infants who develop severe viral respiratory infections are more likely to have asthma later in childhood. There has been progress in understanding the pathogenesis of viral respiratory illnesses, and this has led to new insights into how these processes might differ in asthma. Several host factors, including respiratory allergy and virus-induced interferon responses, modify the risk of virus-induced wheezing. In the absence of effective antiviral therapies, treatment of virus-induced wheezing and exacerbations of asthma can be challenging, and studies evaluating current treatment strategies are reviewed. Understanding the host-pathogen interactions that determine the severity of respiratory illnesses and long-term sequelae is likely to be of great help in identifying at-risk individuals, and in designing new and more effective treatments.

Indexed as

AsthmaRespiratory Syncytial Virus InfectionsRespiratory Tract InfectionsVirus DiseasesAnti-Inflammatory AgentsAntiviral AgentsBronchial HyperreactivityBronchiolitis, ViralBronchodilator AgentsChildChild, PreschoolHumansHygieneHypersensitivityInfantInfant, NewbornAnti-Inflammatory AgentsAntiviral AgentsBronchodilator AgentsLeukotriene Antagonists

Identifiers

PMID18820588
PMCPMC3913380
OpenAlexW2070218296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.