ArticleNucleic acids research2008
Nuclear export competence of pre-40S subunits in fission yeast requires the ribosomal protein Rps2.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Several proteins derived from serum exosomes are potential biomarkers for diagnosis and progression of sudden sensorineural hearing loss.Frontiers in neurology · 2025Article
- The conserved RNA-binding protein Seb1 promotes cotranscriptional ribosomal RNA processing by controlling RNA polymerase I progression.Nature communications · 2023Article
- Ribosomal Protein uS5 and Friends: Protein-Protein Interactions Involved in Ribosome Assembly and Beyond.Biomolecules · 2023Review
- A ZTF-7/RPS-2 complex mediates the cold-warm response in C. elegans.PLoS genetics · 2023Article
- Tsr4 Is a Cytoplasmic Chaperone for the Ribosomal Protein Rps2 in Saccharomyces cerevisiae.Molecular and cellular biology · 2019Article
- The 40S ribosomal protein uS5 (RPS2) assembles into an extraribosomal complex with human ZNF277 that competes with the PRMT3-uS5 interaction.The Journal of biological chemistry · 2019Article
- Human PDCD2L Is an Export Substrate of CRM1 That Associates with 40S Ribosomal Subunit Precursors.Molecular and cellular biology · 2016Article
- Zfrp8/PDCD2 Interacts with RpS2 Connecting Ribosome Maturation and Gene-Specific Translation.PloS one · 2016Article
- Rps5-Rps16 communication is essential for efficient translation initiation in yeast S. cerevisiae.Nucleic acids research · 2014Article
- Methylation of yeast ribosomal protein S2 is elevated during stationary phase growth conditions.Biochemical and biophysical research communications · 2014Article
- The von Hippel-Lindau protein pVHL inhibits ribosome biogenesis and protein synthesis.The Journal of biological chemistry · 2013Article
- The yeast nuclear pore complex and transport through it.Genetics · 2012Article
- Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2.Molecular bioSystems · 2011Article
- Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits.The Journal of cell biology · 2010Article
- Yeast strains with N-terminally truncated ribosomal protein S5: implications for the evolution, structure and function of the Rps5/Rps7 proteins.Nucleic acids research · 2010Article
- Rmt1 catalyzes zinc-finger independent arginine methylation of ribosomal protein Rps2 in Saccharomyces cerevisiae.Biochemical and biophysical research communications · 2010Article
- A methyltransferase-independent function for Rmt3 in ribosomal subunit homeostasis.The Journal of biological chemistry · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ribosome biogenesis is an evolutionarily conserved pathway that requires ribosomal and nonribosomal proteins. Here, we investigated the role of the ribosomal protein S2 (Rps2) in fission yeast ribosome synthesis. As for many budding yeast ribosomal proteins, Rps2 was essential for cell viability in fission yeast and the genetic depletion of Rps2 caused a complete inhibition of 40S ribosomal subunit production. The pattern of pre-rRNA processing upon depletion of Rps2 revealed a reduction of 27SA(2) pre-rRNAs and the concomitant production of 21S rRNA precursors, consistent with a role for Rps2 in efficient cleavage at site A(2) within the 32S pre-rRNA. Importantly, kinetics of pre-rRNA accumulation as determined by rRNA pulse-chases assays indicated that a small fraction of 35S precursors matured into 20S-containing particles, suggesting that most 40S precursors were rapidly degraded in the absence of Rps2. Analysis of steady-state RNA levels revealed that some pre-40S particles were produced in Rps2-depleted cells, but that these precursors were retained in the nucleolus. Our findings suggest a role for Rps2 in a mechanism that monitors pre-40S export competence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.