ArticleApplied and environmental microbiology2008
Effects of therapeutic ceftiofur administration to dairy cattle on Escherichia coli dynamics in the intestinal tract.
Article in Applied and environmental microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed.
- Population dynamics of enteric Salmonella in response to antimicrobial use in beef feedlot cattle.Scientific reports · 2017Trial
- Long-term effects of systemic ceftiofur and ampicillin on the abundance and duration of shedding of resistant Gram-negative bacteria in the feces of healthy dairy cows: a randomized clinical trial.Frontiers in veterinary science · 2026Article
- Assessing the Impacts of Dairy Farm Antimicrobial Use on the Bovine Fecal Microbiome.Animals : an open access journal from MDPI · 2025Article
- Impact of Parenteral Ceftiofur on Developmental Dynamics of Early Life Fecal Microbiota and Antibiotic Resistome in Neonatal Lambs.Antibiotics (Basel, Switzerland) · 2025Article
- Impact of systemic antimicrobial therapy on the faecal microbiome in symptomatic dairy cows.PloS one · 2024Article
- Article
- Persistent effects of intramammary ceftiofur treatment on the gut microbiome and antibiotic resistance in dairy cattle.Animal microbiome · 2023Article
- Prevalence and antimicrobial resistance profiles of extended-spectrum beta-lactamase-producingFrontiers in veterinary science · 2023Article
- Intestinal Exposure to Ceftiofur and Cefquinome after Intramuscular Treatment and the Impact of Ceftiofur on the Pig Fecal Microbiome and Resistome.Antibiotics (Basel, Switzerland) · 2022Article
- Prevalence and Profiles of Antibiotic Resistance GenesMicroorganisms · 2022Article
- Antimicrobial resistance in wildlife and in the built environment in a wildlife rehabilitation center.One health (Amsterdam, Netherlands) · 2021Article
- Estimating the Rates of Acquisition and loss of Resistance ofMicroorganisms · 2021Article
- Article
- Effect of Antimicrobial Treatment on the Dynamics of Ceftiofur Resistance in Enterobacteriaceae from Adult California Dairy Cows.Microorganisms · 2021Article
- Impact of Ceftiofur Administration in Steers on the Prevalence and Antimicrobial Resistance ofMicroorganisms · 2021Article
- Article
- Antibiotics and Antibiotic Resistance Genes in Animal Manure - Consequences of Its Application in Agriculture.Frontiers in microbiology · 2021Review
- Dynamic Changes in Antimicrobial Resistance in FecalAnimals : an open access journal from MDPI · 2020Article
- Pharmacodynamics of Ceftiofur Selected by Genomic and Proteomic Approaches ofInternational journal of genomics · 2020Article
- A one health perspective on dairy production and dairy food safety.One health (Amsterdam, Netherlands) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The goal of this study was to follow ceftiofur-treated and untreated cattle in a normally functioning dairy to examine enteric Escherichia coli for changes in antibiotic resistance profiles and genetic diversity. Prior to treatment, all of the bacteria cultured from the cows were susceptible to ceftiofur. Ceftiofur-resistant E. coli was only isolated from treated cows during and immediately following the cessation of treatment, and the 12 bla(CMY-2)-positive isolates clustered into two genetic groups. E. coli bacterial counts dropped significantly in the treated animals (P < 0.027), reflecting a disappearance of the antibiotic-susceptible strains. The resistant bacterial population, however, did not increase in quantity within the treated cows; levels stayed low and were overtaken by a returning susceptible population. There was no difference in the genetic diversities of the E. coli between the treated and untreated cows prior to ceftiofur administration or after the susceptible population of E. coli returned in the treated cows. A cluster analysis of antibiotic susceptibility profiles resulted in six clusters, two of which were multidrug resistant and were comprised solely of isolates from the treated cows immediately following treatment. The antibiotic treatment provided a window to detect the presence of ceftiofur-resistant E. coli but did not appear to cause its emergence or result in its amplification. The finding of resistant isolates following antibiotic treatment is not sufficient to estimate the strength of selection pressure nor is it sufficient to demonstrate a causal link between antibiotic use and the emergence or amplification of resistance.
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