ReviewSeminars in immunology2009
Augmentation of antibody responses by retinoic acid and costimulatory molecules.
Review in Seminars in immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Retinoic Acid (RA): A Critical Immunoregulatory Molecule in Asthma and Allergies.Immunity, inflammation and disease · 2024Review
- Plasma metabolomic characterization of SARS-CoV-2 Omicron infection.Cell death & disease · 2023Article
- Identification of Costimulatory Molecule-Related lncRNAs Associated With Gastric Carcinoma Progression: Evidence From Bioinformatics Analysis and Cell Experiments.Frontiers in genetics · 2022Article
- Multiple Vaccinations and the Enigma of Vaccine Injury.Vaccines · 2020Review
- Impact of Childhood Malnutrition on Host Defense and Infection.Clinical microbiology reviews · 2017Review
- Nanoformulation of synergistic TLR ligands to enhance vaccination against Entamoeba histolytica.Vaccine · 2017Article
- Cocoa Diet and Antibody Immune Response in Preclinical Studies.Frontiers in nutrition · 2017Review
- Article
- Retinoic acid-induced IgG production in TLR-activated human primary B cells involves ULK1-mediated autophagy.Autophagy · 2015Article
- Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells.Mucosal immunology · 2014Article
- Vitamin A deficiency is associated with gastrointestinal and respiratory morbidity in school-age children.The Journal of nutrition · 2014Observational
- β-Carotene Biosynthesis in Probiotic Bacteria.Probiotics and antimicrobial proteins · 2013Article
- 9-cis-retinoic acid promotes cell adhesion through integrin dependent and independent mechanisms across immune lineages.The Journal of nutritional biochemistry · 2013Article
- The effects of cocoa on the immune system.Frontiers in pharmacology · 2013Article
- Vitamin A and retinoic acid in T cell-related immunity.The American journal of clinical nutrition · 2012Review
- All-trans-retinoic acid and the glycolipid α-galactosylceramide combined reduce breast tumor growth and lung metastasis in a 4T1 murine breast tumor model.Nutrition and cancer · 2012Article
- Retinoic acid and α-galactosylceramide differentially regulate B cell activation in vitro and augment antibody production in vivo.Clinical and vaccine immunology : CVI · 2011Article
- Vitamin A and retinoic acid in the regulation of B-cell development and antibody production.Vitamins and hormones · 2011Review
- All-trans-retinoic acid and Erk1/2 signaling synergistically regulate the expression of CD300B in human monocytic cells.Cellular immunology · 2011Article
- Educating CD4 T cells with vaccine adjuvants: lessons from lipopolysaccharide.Trends in immunology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Antibody production is crucial for a successful vaccine response. Beyond the ability of vitamin A (VA) and its active metabolite, all-trans-retinoic acid (RA) to restore growth in VA-deficient animals, supplementation with VA and/or treatment with RA can augment antibody responses in both VA-deficient and VA-adequate animals. RA alone, and in combination with stimuli that are ligands for the Toll-like receptor family, can augment the adaptive immune response leading to a heightened primary antibody response, and a stronger recall response upon restimulation. Mechanisms may include regulation of cell populations, type 1/type 2 cytokines, and B cell-related transcription factors, leading to accelerated B cell maturation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.