ArticleCurrent protocols in cell biology2008
Use of hyaluronan-derived hydrogels for three-dimensional cell culture and tumor xenografts.
Article in Current protocols in cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Cell-extracellular matrix mechanotransduction in 3D.Nature reviews. Molecular cell biology · 2023Review
- Three-Dimensional Evaluation of the Cytotoxicity and Antibacterial Properties of Alpha Lipoic Acid-Capped Silver Nanoparticle Constructs for Oral Applications.Nanomaterials (Basel, Switzerland) · 2023Article
- Stability Evaluation and Degradation Studies of DACBiomolecules · 2020Article
- Comparison of Hydrogels for the Development of Well-Defined 3D Cancer Models of Breast Cancer and Melanoma.Cancers · 2020Article
- From Shape to Function: The Next Step in Bioprinting.Advanced materials (Deerfield Beach, Fla.) · 2020Review
- RAP2 mediates mechanoresponses of the Hippo pathway.Nature · 2018Article
- Hyaluronan content governs tissue stiffness in pancreatic islet inflammation.The Journal of biological chemistry · 2018Article
- Native-mimicking in vitro microenvironment: an elusive and seductive future for tumor modeling and tissue engineering.Journal of biological engineering · 2018Review
- Article
- A tunable hydrogel system for long-term release of cell-secreted cytokines and bioprinted in situ wound cell delivery.Journal of biomedical materials research. Part B, Applied biomaterials · 2017Article
- Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink.Journal of visualized experiments : JoVE · 2016Article
- Review
- Liver-Tumor Hybrid Organoids for Modeling Tumor Growth and Drug Response In Vitro.Annals of biomedical engineering · 2015Article
- Growth factor and ultrasound-assisted bioreactor synergism for human mesenchymal stem cell chondrogenesis.Journal of tissue engineering · 2015Article
- Article
- Applications and emerging trends of hyaluronic acid in tissue engineering, as a dermal filler and in osteoarthritis treatment.Acta biomaterialia · 2013Review
- IL-10 induction from implants delivering pancreatic islets and hyaluronan.Journal of diabetes research · 2013Article
- Gel encapsulation of glucose nanosensors for prolonged in vivo lifetime.Journal of diabetes science and technology · 2013Article
- Tissue specific synthetic ECM hydrogels for 3-D in vitro maintenance of hepatocyte function.Biomaterials · 2012Article
- Hydrogels with time-dependent material properties enhance cardiomyocyte differentiation in vitro.Biomaterials · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The practice of in vitro three-dimensional (3-D) cell culture has lagged behind the realization that classical two-dimensional (2-D) culture on plastic surfaces fails to mirror normal cell biology. Biologically, a complex network of proteins and proteoglycans that constitute the extracellular matrix (ECM) surrounds every cell. To recapitulate the normal cellular behavior, scaffolds (ECM analogs) that reconstitute the essential biological cues are required. This unit describes the 3-D cell culture and tumor engineering applications of Extracel, a novel semisynthetic ECM (sECM), based on cross-linked derivatives of hyaluronan and gelatin. A simplified cell encapsulation and pseudo-3-D culturing (on top of hydrogels) protocol is provided. In addition, the use of this sECM as a vehicle to obtain tumor xenografts with improved take rates and tumor growth is presented. These engineered tumors can be used to evaluate anticancer therapies under physiologically relevant conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.