ArticleProceedings of the National Academy of Sciences of the United States of America1991
Acetylcholine receptor-inducing activity stimulates expression of the epsilon-subunit gene of the muscle acetylcholine receptor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 159 citations in OpenAlex.
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- A Truncating Variant ofJournal of pediatric genetics · 2022Article
- Nicotinic acetylcholine receptors: Conventional and unconventional ligands and signaling.Neuropharmacology · 2020Review
- Extracellular signal-regulated kinases 1 and 2 regulate neuromuscular junction and myofiber phenotypes in mammalian skeletal muscle.Neuroscience letters · 2020Review
- A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction.eLife · 2019Article
- Impaired Expression of Neuregulin 1 and Nicotinic Acetylcholine Receptor β4 Subunit in Diverticular Disease.Frontiers in cellular neuroscience · 2019Article
- A novel approach for targeted delivery to motoneurons using cholera toxin-B modified protocells.Journal of neuroscience methods · 2016Article
- The ER structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3.Science signaling · 2016Article
- Artemin growth factor increases nicotinic cholinergic receptor subunit expression and activity in nociceptive sensory neurons.Molecular pain · 2014Article
- Neuregulin in cardiovascular development and disease.Circulation research · 2012Review
- Serum Neuregulin-1beta as a Biomarker of Cardiovascular Fitness.The open biomarkers journal · 2009Article
- Neuregulin induces the expression of transcription factors and myosin heavy chains typical of muscle spindles in cultured human muscle.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Overlapping of MINK and CHRNE gene loci in the course of mammalian evolution.Nucleic acids research · 2002Article
- Agrin differentially regulates the rates of axonal and dendritic elongation in cultured hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- The Agrin/MuSK signaling pathway is spatially segregated from the neuregulin/ErbB receptor signaling pathway at the neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Neuregulin induces GABA(A) receptor subunit expression and neurite outgrowth in cerebellar granule cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Essential roles of c-JUN and c-JUN N-terminal kinase (JNK) in neuregulin-increased expression of the acetylcholine receptor epsilon-subunit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Processing of ARIA and release from isolated nerve terminals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1999Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motor neurons regulate the transcription of acetylcholine receptor subunit genes in postsynaptic muscle fibers both through muscle electrical activity produced by motor neuron acetylcholine release and by mechanisms independent of such transmitter release. Factors secreted by the motor neuron may mediate activity-independent regulation, including the postnatal switch from alpha 2 beta gamma delta (embryonic type) to alpha 2 beta epsilon delta (adult type) receptors. We have investigated the effect of putative trophic factors, agents affecting second-messenger systems, and muscle activity on the levels of acetylcholine receptor subunit mRNAs in primary mouse muscle cultures. We found that ARIA (acetylcholine receptor-inducing activity), a 42-kDa glycoprotein purified on the basis of its ability to increase the synthesis of acetylcholine receptors in chick myotubes, increases epsilon-subunit mRNA levels up to 10-fold. In addition, ARIA stimulated alpha-, gamma-, and delta-subunit mRNA levels 2-fold but had no effect on the expression of the beta-subunit gene. These effects of ARIA were independent of muscle activity, and they were not mimicked by calcitonin gene-related peptide nor by thyroxine, forskolin, phorbol 12-myristate 13-acetate, the calcium ionophore A23187, basic fibroblast growth factor, or transforming growth factor beta. Based on these data, we suggest that ARIA may act at the mammalian neuromuscular junction to induce adult-type acetylcholine receptors.
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