ArticleActa diabetologica2009
Glycaemic variability and inflammation in subjects with metabolic syndrome.
Article in Acta diabetologica, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01524705 (FLAT-SUGAR), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
FLAT-SUGAR: FLuctuATion Reduction With inSULin and Glp-1 Added togetheR
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The effects of kratomFrontiers in pharmacology · 2025Pooled it
- Non-Invasive Continuous Glucose Monitoring in Patients Without Diabetes: Use in Cardiovascular Prevention-A Systematic Review.Sensors (Basel, Switzerland) · 2025Pooled it
- Higher adiposity predicts greater intra-individual inconsistencies in postprandial glycemic measurements-an analysis of three randomized controlled trials in Asian populations.European journal of clinical nutrition · 2024Trial
- Aerobic and combined exercise sessions reduce glucose variability in type 2 diabetes: crossover randomized trial.PloS one · 2013Trial
- Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome.Nutrition (Burbank, Los Angeles County, Calif.) · 2011Trial
- Glucose Dysregulation as a Driver of Autoimmune Mimicry, Inflammation, and Psychiatric Symptoms: A Narrative Review.Biology · 2026Review
- The Impact of Glycaemic Variability on Vascular Dysfunction in Diabetes.Biomolecules · 2025Review
- Use of Continuous Glucose Monitors by People Without Diabetes: An Idea Whose Time Has Come?Journal of diabetes science and technology · 2023Article
- Metabolic syndrome associated with higher glycemic variability in type 1 diabetes: A multicenter cross-sectional study in china.Frontiers in endocrinology · 2022Article
- Glucose Variability: How Does It Work?International journal of molecular sciences · 2021Review
- Non-invasive wearables for remote monitoring of HbA1c and glucose variability: proof of concept.BMJ open diabetes research & care · 2021Article
- Bioinformatic Reconstruction and Analysis of Gene Networks Related to Glucose Variability in Diabetes and Its Complications.International journal of molecular sciences · 2020Article
- Glycaemic variability: The under-recognized therapeutic target in type 1 diabetes care.Diabetes, obesity & metabolism · 2019Review
- Effect of exercise on glucose variability in healthy subjects: randomized crossover trial.Biology of sport · 2019Article
- Excessive visit-to-visit glycemic variability independently deteriorates the progression of endothelial and renal dysfunction in patients with type 2 diabetes mellitus.BMC nephrology · 2016Article
- Glycemic variability in nondiabetic morbidly obese persons: results of an observational study and review of the literature.Journal of diabetes science and technology · 2014Observational
- Relationship between fluctuations in glucose levels measured by continuous glucose monitoring and vascular endothelial dysfunction in type 2 diabetes mellitus.Cardiovascular diabetology · 2013Article
- Management of hyperglycemia in hospitalized patients.Annals of the New York Academy of Sciences · 2010Review
- Use of continuous glucose monitoring in obesity research: A scoping review.Obesity research & clinical practiceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subjects who develop diabetes have an increased cardiovascular risk even before the appearance of diabetes. The aim of this study was to investigate the glycaemic variability measured by continuous glucose monitoring (CGM CV%) in nondiabetic subjects with metabolic syndrome (MS) and to explore if glycaemic variability was associated with circulating levels of interleukin-6 (IL-6), a proinflammatory cytokine, or with an anti-inflammatory factor like adiponectin. Three groups of obese subjects with (MS+: 6m, 8f; BMI 33.1+/-1.4 mean+/-SEM) or without metabolic syndrome (MS-: 2m, 4f; BMI 29.2+/-2.2) and with MS associated with type 2 diabetes (MS/T2D: 3m, 5f; BMI 32.9+/-1.4) were investigated. The glycaemic variability was measured in all subjects in terms of CV% of the glycaemic values obtained every 3 min during the course of a 48 h CGM performed using a subcutaneous glucose sensor. The average CGM CV% increased from MS- group (21.1%) to the MS+ group (23.9%) and to the MS+/T2D group (27.4%) but it was not correlated to the CGM mean glycaemia (r=0.20; P=ns). In some instances, CGM CV% was found higher in MS+ subjects than in some MS+ T2D ones. Stepwise multiple correlation analysis showed that IL-6 predicted CGM CV% (R(2)=0.35, beta=0.13; P<0.05) independently from BMI, waist circumference, adiponectin and insulin concentrations. In conclusion, the CGM CV% may contribute to better describe the individual metabolic state and to understand the pathogenesis of endothelial dysfunction in non diabetic subjects with MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.