ArticlePLoS pathogens2008
Capnocytophaga canimorsus: a human pathogen feeding at the surface of epithelial cells and phagocytes.
Article in PLoS pathogens, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 70 citations in OpenAlex.
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- Capnocytophaga canimorsus from Dog Saliva Exposure Causing Severe Sepsis in a Healthy Adult: A Case Report.The American journal of case reports · 2025Article
- LolA and LolB are conserved in Bacteroidota and are crucial for gliding motility and Type IX secretion.Communications biology · 2025Article
- The Association between Broiler Litter Microbiota and the Supplementation ofAnimals : an open access journal from MDPI · 2024Article
- Figurate urticaria as a presenting sign ofJAAD case reports · 2023Article
- Genomics ofPathogens (Basel, Switzerland) · 2023Article
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- The Great pretender: the first case of septic shock due to Capnocytophaga canimorsus in Sardinia. A Case report and review of the literature.Journal of public health research · 2022Article
- Exposure of Thomsen-Friedenreich Antigen on the Renal Tubules of a Patient with Capnocytophaga Infection-induced Acute Kidney Injury.Internal medicine (Tokyo, Japan) · 2022Article
- Fatal septic shock caused byGerms · 2022Article
- Multiple evolutionary origins reflect the importance of sialic acid transporters in the colonization potential of bacterial pathogens and commensals.Microbial genomics · 2021Article
- Dual RNAseq highlights the kinetics of skin microbiome and fish host responsiveness to bacterial infection.Animal microbiome · 2021Article
- Biofilm Spreading by the Adhesin-Dependent Gliding Motility ofInternational journal of molecular sciences · 2021Article
- Advancements in CharacterizingPathogens (Basel, Switzerland) · 2020Review
- Glycan cross-feeding supports mutualism between Fusobacterium and the vaginal microbiota.PLoS biology · 2020Article
- Capnocytophagia canimorsus - Severe sepsis in a previously well individual with no evidence of a cat or dog bite. A case report.Annals of medicine and surgery (2012) · 2020Article
- A case of fulminant sepsis caused byIDCases · 2020Article
- An asplenic with life-threateningIDCases · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Capnocytophaga canimorsus, a commensal bacterium of the canine oral flora, has been repeatedly isolated since 1976 from severe human infections transmitted by dog bites. Here, we show that C. canimorsus exhibits robust growth when it is in direct contact with mammalian cells, including phagocytes. This property was found to be dependent on a surface-exposed sialidase allowing C. canimorsus to utilize internal aminosugars of glycan chains from host cell glycoproteins. Although sialidase probably evolved to sustain commensalism, by releasing carbohydrates from mucosal surfaces, it also contributed to bacterial persistence in a murine infection model: the wild type, but not the sialidase-deficient mutant, grew and persisted, both when infected singly or in competition. This study reveals an example of pathogenic bacteria feeding on mammalian cells, including phagocytes by deglycosylation of host glycans, and it illustrates how the adaptation of a commensal to its ecological niche in the host, here the dog's oral cavity, contributes to being a potential pathogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.