ReviewPLoS genetics2008
A review of family-based tests for linkage disequilibrium between a quantitative trait and a genetic marker.
Review in PLoS genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Deconstructing a Syndrome: Genomic Insights Into PCOS Causal Mechanisms and Classification.Endocrine reviews · 2022Article
- Benchmarking statistical methods for analyzing parent-child dyads in genetic association studies.Genetic epidemiology · 2022Review
- Causal inference in genetic trio studies.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Candidate-gene association analysis for a continuous phenotype with a spike at zero using parent-offspring trios.Journal of applied statistics · 2020Article
- Linkage Analysis of the Chromosome 5q31-33 Region Identifies JAKMIP2 as a Risk Factor for Graves' Disease in the Chinese Han Population.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Uncovering the Genetic Architectures of Quantitative Traits.Computational and structural biotechnology journal · 2016Review
- The Role of Metabotropic Glutamate Receptor Genes in Schizophrenia.Current neuropharmacology · 2016Review
- Statistical equivalent of the classical TDT for quantitative traits and multivariate phenotypes.Journal of genetics · 2015Review
- The Fourth Law of Behavior Genetics.Current directions in psychological science · 2015Article
- Article
- LEVERAGING LOCAL IDENTITY-BY-DESCENT INCREASES THE POWER OF CASE/CONTROL GWAS WITH RELATED INDIVIDUALS.The annals of applied statistics · 2014Article
- Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Article
- A statistical framework for testing the causal effects of fetal drive.Frontiers in genetics · 2014Article
- The causal meaning of Fisher's average effect.Genetics research · 2013Article
- Twins for epigenetic studies of human aging and development.Ageing research reviews · 2013Review
- Statistical distributions of test statistics used for quantitative trait association mapping in structured populations.Genetics, selection, evolution : GSE · 2012Article
- Family-based designs for genome-wide association studies.Nature reviews. Genetics · 2011Review
- Replication of CNTNAP2 association with nonword repetition and support for FOXP2 association with timed reading and motor activities in a dyslexia family sample.Journal of neurodevelopmental disorders · 2011Article
- A rapid generalized least squares model for a genome-wide quantitative trait association analysis in families.Human heredity · 2011Article
- Dissecting complex phenotypes using the genomics of twins.Functional & integrative genomics · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Quantitative trait transmission/disequilibrium tests (quantitative TDTs) are commonly used in family-based genetic association studies of quantitative traits. Despite the availability of various quantitative TDTs, some users are not aware of the properties of these tests and the relationships between them. This review aims at outlining the broad features of the various quantitative TDT procedures carried out in the frequently used QTDT and FBAT packages. Specifically, we discuss the "Rabinowitz" and the "Monks-Kaplan" procedures, as well as the various "Abecasis" and "Allison" regression-based procedures. We focus on the models assumed in these tests and the relationships between them. Moreover, we discuss what hypotheses are tested by the various quantitative TDTs, what testing procedures are best suited to various forms of data, and whether the regression-based tests overcome population stratification problems. Finally, we comment on power considerations in the choice of the test to be used. We hope this brief review will shed light on the similarities and differences of the various quantitative TDTs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.