ArticleKidney international2009
Regulation of oxygen utilization by angiotensin II in chronic kidney disease.
Article in Kidney international, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- Linking renal hypoxia and oxidative stress in chronic kidney disease: Based on clinical subjects and animal models.Biomolecules & biomedicine · 2024Article
- Microvascular dysfunction following cardiopulmonary bypass plays a central role in postoperative organ dysfunction.Frontiers in medicine · 2023Review
- Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension.Nature communications · 2022Article
- Shen Shuai II Recipe Attenuates Renal Interstitial Fibrosis by Improving Hypoxia via the IL-1Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Shen Shuai II Recipe Attenuates Apoptosis in 5/6 Renal Ablation/Infarction Rats by Inhibiting p53 and the Mitochondrial Pathway of Apoptosis.Oxidative medicine and cellular longevity · 2020Article
- Shen Shuai IIRecipe attenuates renal injury and fibrosis in chronic kidney disease by regulating NLRP3 inflammasome and Sirt1/Smad3 deacetylation pathway.BMC complementary and alternative medicine · 2019Article
- Magnesium lithospermate B improves renal hemodynamics and reduces renal oxygen consumption in 5/6th renal ablation/infarction rats.BMC nephrology · 2019Article
- ShenShuai II Recipe Attenuates Apoptosis and Renal Fibrosis in Chronic Kidney Disease by Increasing Renal Blood Flow and Improving Oxygen Consumption.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- The novel nitric oxide donor PDNO attenuates ovine ischemia-reperfusion induced renal failure.Intensive care medicine experimental · 2017Article
- Hypoxia-inducible factor-1α activation improves renal oxygenation and mitochondrial function in early chronic kidney disease.American journal of physiology. Renal physiology · 2017Article
- Renal Oxygenation in the Pathophysiology of Chronic Kidney Disease.Frontiers in physiology · 2017Review
- Renal Hypoxia in CKD; Pathophysiology and Detecting Methods.Frontiers in physiology · 2017Review
- Recent advances in renal hypoxia: insights from bench experiments and computer simulations.American journal of physiology. Renal physiology · 2016Review
- Mitochondrial uncoupling proteins regulate angiotensin-converting enzyme expression: crosstalk between cellular and endocrine metabolic regulators suggested by RNA interference and genetic studies.Inside the cell · 2016Article
- Interactions between HIF-1α and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease.American journal of physiology. Renal physiology · 2015Article
- Recent advances in renal hemodynamics: insights from bench experiments and computer simulations.American journal of physiology. Renal physiology · 2015Review
- Inhibition of the renin-angiotensin system affects kidney tissue oxygenation evaluated by magnetic resonance imaging in patients with chronic kidney disease.Journal of clinical hypertension (Greenwich, Conn.) · 2014Article
- Chronic diuretic therapy attenuates renal BOLD magnetic resonance response to an acute furosemide stimulus.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2014Article
- Induction of AMPK activity corrects early pathophysiological alterations in the subtotal nephrectomy model of chronic kidney disease.American journal of physiology. Renal physiology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Angiotensin II blockade delays progression of chronic kidney disease by modifying intrarenal hemodynamics, but the effects on metabolic adaptations are unknown. Using the remnant kidney model of chronic kidney disease in rats, we measured the effects of combined angiotensin II blockade with captopril and losartan on renal oxygen consumption (QO(2)) and factors influencing QO(2). Remnant kidneys had proteinuria and reductions in the glomerular filtration rate (GFR), renal blood flow (RBF) and nitric oxide synthase-1 protein expression while QO(2), factored by sodium reabsorption (QO(2)/TNa), was markedly increased. Combined blockade treatment normalized these parameters while increasing sodium reabsorption but, since QO(2) was unchanged, QO(2)/TNa also normalized. Triple antihypertensive therapy, to control blood pressure, and treatment with lysine, to increase GFR and RBF, did not normalize QO(2)/TNa, suggesting a specific effect of angiotensin II in elevating QO(2)/TNa. Inhibition of nitric oxide synthase increased QO(2) in the kidney of sham-operated rats but not in the remnant kidney of untreated rats. Our study shows that combined captopril and losartan treatment normalized QO(2)/TNa and functional nitric oxide activity in the remnant kidney independent of blood pressure and GFR effects, suggesting that other mechanisms in addition to hemodynamics underlie the benefits of angiotensin II blockade.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.