ArticleArteriosclerosis, thrombosis, and vascular biology2008
Athsq1 is an atherosclerosis modifier locus with dramatic effects on lesion area and prominent accumulation of versican.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Comparison Study on the Effect of Mesenchymal Stem Cells-Conditioned Medium Derived from Adipose and Wharton's Jelly on Versican Gene Expression in Hypoxia.Iranian biomedical journal · 2022Article
- A role for proteoglycans in vascular disease.Matrix biology : journal of the International Society for Matrix Biology · 2018Review
- Analysis of the 9p21.3 sequence associated with coronary artery disease reveals a tendency for duplication in a CAD patient.Oncotarget · 2018Article
- Enhanced Megakaryopoiesis and Platelet Activity in Hypercholesterolemic, B6-Ldlr-/-, Cdkn2a-Deficient Mice.Circulation. Cardiovascular genetics · 2016Article
- Article
- Versican is upregulated in circulating monocytes in patients with systemic sclerosis and amplifies a CCL2-mediated pathogenic loop.Arthritis research & therapy · 2013Article
- Pegylation of high-density lipoprotein decreases plasma clearance and enhances antiatherogenic activity.Circulation research · 2013Article
- Pro-inflammatory phenotype of COPD fibroblasts not compatible with repair in COPD lung.Journal of cellular and molecular medicine · 2012Article
- Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice.Circulation. Cardiovascular genetics · 2012Article
- RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration.The Journal of clinical investigation · 2012Article
- Beyond genome-wide association studies: the usefulness of mouse genetics in understanding the complex etiology of atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- Cdkn2a is an atherosclerosis modifier locus that regulates monocyte/macrophage proliferation.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
- Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease.Developmental biology · 2011Article
- Neointima formed by arterial smooth muscle cells expressing versican variant V3 is resistant to lipid and macrophage accumulation.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
- Developing vasculature and stroma in engineered human myocardium.Tissue engineering. Part A · 2011Article
- Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk.PLoS genetics · 2010Article
- Synthesis and organization of hyaluronan and versican by embryonic stem cells undergoing embryoid body differentiation.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Article
Corrections and comments
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Authors and funding
15 authors at 1 institution.
Funding
Abstract
objectiveSusceptibility to atherosclerosis is genetically complex, and modifier genes that do not operate via traditional risk factors are largely unknown. A mouse genetics approach can simplify the genetic analysis and provide tools for mechanistic studies. METHODS AND
resultsWe previously identified atherosclerosis susceptibility QTL (Athsq1) on chromosome 4 acting independently of systemic risk factors. We now report confirmation of this locus in congenic strains carrying the MOLF-derived susceptibility allele in the C57BL/6J-Ldlr(-/-) genetic background. Homozygous congenic mice exhibited up to 4.5-fold greater lesion area compared to noncongenic littermates (P<0.0001). Analysis of extracellular matrix composition revealed prominent accumulation of versican, a presumed proatherogenic matrix component abundant in human lesions but almost absent in the widely-used C57BL/6 murine atherosclerosis model. The results of a bone marrow transplantation experiment suggested that both accelerated lesion development and versican accumulation are mediated, at least in part, by macrophages. Interestingly, comparative mapping revealed that the Athsq1 congenic interval contains the mouse region homologous to a widely-replicated CHD locus on human chromosome 9p21.
conclusionsThese studies confirm the proatherogenic activity of a novel gene(s) in the MOLF-derived Athsq1 locus and provide in vivo evidence for a causative role of versican in lesion development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.