ArticleProceedings of the National Academy of Sciences of the United States of America2008
New auxin analogs with growth-promoting effects in intact plants reveal a chemical strategy to improve hormone delivery.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 126 citations in OpenAlex.
- O-Fucosyltransferase SPINDLY attenuates auxin-induced fruit growth by inhibiting ARF6/8-coactivator mediator complex interaction in Arabidopsis.Nature communications · 2025Article
- In Vitro Rooting of Poplar: Effects and Metabolism of Dichlorprop Auxin Ester Prodrugs.Plants (Basel, Switzerland) · 2025Article
- Small chemical molecules regulating the phytohormone signalling alter the plant's physiological processes to improve stress adaptation, growth and productivity.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
- Indole-3-propionic acid regulates lateral root development by targeting auxin signaling iniScience · 2024Article
- Article
- Plants and Small Molecules: An Up-and-Coming Synergy.Plants (Basel, Switzerland) · 2023Review
- Identification of a pluripotency-inducing small compound, PLU, that induces callus formationFrontiers in plant science · 2023Article
- Elucidating the importance of the catabolic enzyme, methionine-gamma-lyase, in stresses during Arabidopsis seed development and germination.Frontiers in plant science · 2023Article
- Negative regulation of seed germination by maternal AFB1 and AFB5 in Arabidopsis.Bioscience reports · 2022Article
- The bioactive potential of phytohormones: A review.Biotechnology reports (Amsterdam, Netherlands) · 2022Review
- The interplay of auxin and brassinosteroid signaling tunes root growth under low and different nitrogen forms.Plant physiology · 2022Article
- Bacterial endophytes as indicators of susceptibility to Cercospora Leaf Spot (CLS) disease in Beta vulgaris L.Scientific reports · 2022Article
- A network of stress-related genes regulates hypocotyl elongation downstream of selective auxin perception.Plant physiology · 2021Article
- AFB1 controls rapid auxin signalling through membrane depolarization in Arabidopsis thaliana root.Nature plants · 2021Article
- The chemical compound 'Heatin' stimulates hypocotyl elongation and interferes with the Arabidopsis NIT1-subfamily of nitrilases.The Plant journal : for cell and molecular biology · 2021Article
- Chemical Biology in Auxin Research.Cold Spring Harbor perspectives in biology · 2021Review
- Article
- Chemical Manipulation of Abscisic Acid Signaling: A New Approach to Abiotic and Biotic Stress Management in Agriculture.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- IPyA glucosylation mediates light and temperature signaling to regulate auxin-dependent hypocotyl elongation inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Effects of auxin derivatives on phenotypic plasticity and stress tolerance in five species of the green algaPeerJ · 2020Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Plant growth depends on the integration of environmental cues and phytohormone-signaling pathways. During seedling emergence, elongation of the embryonic stem (hypocotyl) serves as a readout for light and hormone-dependent responses. We screened 10,000 chemicals provided exogenously to light-grown seedlings and identified 100 compounds that promote hypocotyl elongation. Notably, one subset of these chemicals shares structural characteristics with the synthetic auxins, 2,4-dichlorophenoxyacetic acid (2,4-D), and 1-naphthaleneacetic acid (1-NAA); however, traditional auxins (e.g., indole-3-acetic acid [IAA], 2,4-D, 1-NAA) have no effect on hypocotyl elongation. We show that the new compounds act as "proauxins" akin to prodrugs. Our data suggest that these compounds diffuse efficiently to the hypocotyls, where they undergo cleavage at varying rates, releasing functional auxins. To investigate this principle, we applied a masking strategy and designed a pro-2,4-D. Unlike 2,4-D alone, this pro-2,4-D enhanced hypocotyl elongation. We further demonstrated the utility of the proauxins by characterizing auxin responses in light-grown hypocotyls of several auxin receptor mutants. These new compounds thus provide experimental access to a tissue previously inaccessible to exogenous application of auxins. Our studies exemplify the combined power of chemical genetics and biochemical analyses for discovering and refining prohormone analogs with selective activity in specific plant tissues. In addition to the utility of these compounds for addressing questions related to auxin and light-signaling interactions, one can envision using these simple principles to study other plant hormone and small molecule responses in temporally and spatially controlled ways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.