ReviewBiochimica et biophysica acta2008
Ubiquitin and ubiquitin-like specific proteases targeted by infectious pathogens: Emerging patterns and molecular principles.
Review in Biochimica et biophysica acta, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- An integrated transcriptomic and meta-analysis of hepatoma cells reveals factors that influence susceptibility to HCV infection.PloS one · 2011Pooled it
- Synthetic Strategies for Activity-Based Probes to Decode Ubiquitin-Like Modifiers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Genome-Wide Analysis ofInternational journal of molecular sciences · 2023Article
- Using Activity-Based Proteomics for the Quantification of Deubiquitinases in Animal Tissue.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Repurposing the Pathogen Box compounds for identification of potent anti-malarials against blood stages of Plasmodium falciparum with PfUCHL3 inhibitory activity.Scientific reports · 2022Article
- Differential Gene Expression in Host Ubiquitination Processes in Childhood Malarial Anemia.Frontiers in genetics · 2021Article
- The papain-like protease of avian infectious bronchitis virus has deubiquitinating activity.Archives of virology · 2017Article
- Article
- Use of focused ultrasonication in activity-based profiling of deubiquitinating enzymes in tissue.Analytical biochemistry · 2016Article
- Proteomic analyses bring new insights into the effect of a dark stress on lipid biosynthesis in Phaeodactylum tricornutum.Scientific reports · 2016Article
- Deubiquitinases: Novel Therapeutic Targets in Immune Surveillance?Mediators of inflammation · 2016Review
- Interaction of HSP20 with a viral RdRp changes its sub-cellular localization and distribution pattern in plants.Scientific reports · 2015Article
- Deubiquitinases (DUBs) and DUB inhibitors: a patent review.Expert opinion on therapeutic patents · 2015Review
- Diversity of ubiquitin and ISG15 specificity among nairoviruses' viral ovarian tumor domain proteases.Journal of virology · 2013Article
- Article
- A strategy for modulation of enzymes in the ubiquitin system.Science (New York, N.Y.) · 2013Article
- Deubiquitinating enzymes as promising drug targets for infectious diseases.Current pharmaceutical design · 2013Review
- Global analysis of differentially expressed genes and proteins in the wheat callus infected by Agrobacterium tumefaciens.PloS one · 2013Article
- Detection of ubiquitin-proteasome enzymatic activities in cells: application of activity-based probes to inhibitor development.Biochimica et biophysica acta · 2012Review
- Mechanisms of virus immune evasion lead to development from chronic inflammation to cancer formation associated with human papillomavirus infection.Oncology reviews · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Attachment of ubiquitin (Ub) or ubiquitin-like (Ubl) modifiers is a reversible post-translational modification that regulates the fate and function of proteins. In particular, proteolytic enzymes with Ub/Ubl processing activity appear to be more widespread than originally anticipated. It is therefore not surprising that bacterial and viral pathogens have exploited many ways to interfere with Ub/Ubl conjugation, but also de-conjugation. On one hand, pathogens were shown to manipulate host encoded enzymes. On the other hand, pathogen derived sequences of proteases specific for Ub/Ubls are emerging as a common feature shared by many viruses, bacteria and protozoa, and we are at an early stage of understanding how these proteases contribute to the pathogenesis of infection. Whereas some of these proteases share a common origin with mammalian cell encoded hydrolases with specific properties towards Ub/Ubls, most of them have ancient intrinsic functions, such as processing pathogen protein components, and may have acquired the specificity for Ub/Ubls by interacting with mammalian hosts and their immune system throughout evolution. Since many of these proteases are clearly distinct from their mammalian counterparts, they represent attractive targets for drug design against infectious diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.