Evidence map›Paper›PMID 18817395›Full record

ArticleJournal of the American Chemical Society2008

Polymeric PARACEST agents for enhancing MRI contrast sensitivity.

Yunkou Wu, Youfu Zhou, Olivier Ouari, Mark Woods, Piyu Zhao, Todd C Soesbe, Garry E Kiefer, A Dean Sherry

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 72 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. CoAngewandte Chemie (International ed. in English) · 2020
    Article
  5. Article
  6. Protonation of carboxyl groups in EuDOTA-tetraamide complexes results in catalytic prototropic exchange and quenching of the CEST signal.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2017
    Article
  7. Review
  8. Article
  9. Article
  10. MR imaging probes: design and applications.Dalton transactions (Cambridge, England : 2003) · 2015
    Review
  11. Article
  12. Review
  13. A europium(III)-based PARACEST agent for sensing singlet oxygen by MRI.Dalton transactions (Cambridge, England : 2003) · 2013
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Molecular imaging probe development: a chemistry perspective.American journal of nuclear medicine and molecular imaging · 2012
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yunkou WuDepartment of Chemistry, University of Texas at Dallas, P.O. Box 830668, Richardson, Texas 75083, USA.
Youfu Zhou
Olivier Ouari
Mark Woods
Piyu Zhao
Todd C Soesbe
Garry E Kiefer
A Dean Sherry
Advanced Imaging Research (United States) · USThe University of Texas Southwestern Medical Center · US

Funding

YTTRIUM HYPERPOLARIZATIONP41RR002584 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI MASON, RALPH P. · 1985 to 2011
$14.3M
PARACEST Agents: Optimization for Human MR ImagingR01EB004582 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI LENKINSKI, ROBERT E · 2006 to 2014
$7.5M
PARACEST AGENTS FOR MOLECULAR IMAGING OF CANCER BY MRIR01CA115531 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI SHERRY, DEAN · 2005 to 2021
$4.2M
Rational control of water exchange in Gd3+ complexesR21EB004285 · NIBIB · MACROCYCLICS, INC. · PI WOODS, MARK · 2004 to 2005
$255k
NCI NIH HHS CA115531NCI NIH HHS R01 CA115531NCRR NIH HHS P41 RR002584NCRR NIH HHS RR02584NIBIB NIH HHS EB04285NIBIB NIH HHS R01 EB004582NIBIB NIH HHS R21 EB004285
6 · The paper itself

Abstract

Linear polymers of PARACEST agents were prepared by using classical free radical chain polymerization conditions. The Eu3+-polymers exhibited similar intermediate-to-slow water exchange and CEST characteristics as the Eu3+-monomers. This provided an avenue to lower the detection limit of these imaging agents substantially and makes them potentially useful as MRI sensors for molecular imaging.

Indexed as

MagneticsChelating AgentsContrast MediaEuropiumImage EnhancementMagnetic Resonance ImagingMolecular StructurePolymersSensitivity and SpecificityChelating AgentsContrast MediaEuropiumPolymers

Identifiers

PMID18817395
PMCPMC2723842
OpenAlexW2017737903

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.