ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2008
Kinetic and mechanical analysis of live tube morphogenesis.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- The dynamics of tubulogenesis in development and disease.Development (Cambridge, England) · 2025Review
- The ion channel Anoctamin 10/TMEM16K coordinates organ morphogenesis across scales in the urochordate notochord.PLoS biology · 2024Article
- Lateral adherens junctions mediate a supracellular actomyosin cortex in drosophila trachea.iScience · 2023Article
- Ribbon boosts ribosomal protein gene expression to coordinate organ form and function.The Journal of cell biology · 2022Article
- Multiple Requirements for Rab GTPases in the Development ofG3 (Bethesda, Md.) · 2020Article
- Mammary epithelial tubes elongate through MAPK-dependent coordination of cell migration.Development (Cambridge, England) · 2016Article
- Regulation of Gonad Morphogenesis in Drosophila melanogaster by BTB Family Transcription Factors.PloS one · 2016Article
- Ribbon regulates morphogenesis of the Drosophila embryonic salivary gland through transcriptional activation and repression.Developmental biology · 2016Article
- Seamless tube shape is constrained by endocytosis-dependent regulation of active Moesin.Current biology : CB · 2014Article
- Tubulogenesis.Development (Cambridge, England) · 2013Review
- The secreted AdamTS-A metalloprotease is required for collective cell migration.Development (Cambridge, England) · 2013Article
- A pathway for unicellular tube extension depending on the lymphatic vessel determinant Prox1 and on osmoregulation.Nature cell biology · 2013Article
- Drosophila as a model for epithelial tube formation.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Review
- Rho GTPase controls Drosophila salivary gland lumen size through regulation of the actin cytoskeleton and Moesin.Development (Cambridge, England) · 2011Article
- Membrane traffic as a coordinator of cell migration and junction remodeling.Communicative & integrative biology · 2011Article
- Arp2/3 promotes junction formation and maintenance in the Caenorhabditis elegans intestine by regulating membrane association of apical proteins.Molecular biology of the cell · 2011Article
- Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis.The Journal of biological chemistry · 2011Article
- Pak1 control of E-cadherin endocytosis regulates salivary gland lumen size and shape.Development (Cambridge, England) · 2010Article
- Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration.Developmental biology · 2010Review
- Emergent morphogenesis: elastic mechanics of a self-deforming tissue.Journal of biomechanics · 2010Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Ribbon is a nuclear Broad Tramtrack Bric-a-brac (BTB) -domain protein required for morphogenesis of the salivary gland and trachea. We recently showed that ribbon mutants exhibit decreased Crumbs and Rab11-coincident apical vesicles and increased apical Moesin activity and microvillar structure during tube elongation. To learn how these molecular and morphological changes affect the dynamics of tubulogenesis, we optimized an advanced two-photon microscope to enable high-resolution live imaging of the salivary gland and trachea. Live imaging revealed that ribbon mutant tissues exhibit slowed and incomplete lumenal morphogenesis, consistent with previously described apical defects. Because Moesin activity correlates with cortical stiffness, we hypothesize that ribbon mutants suffer from increased apical stiffness during morphogenesis. We develop this hypothesis through mechanical analysis, using the advantages of live imaging to construct computational elastic and analytical viscoelastic models of tube elongation, which suggest that ribbon mutant tubes exhibit three- to fivefold increased apical stiffness and twofold increased effective apical viscosity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.