ArticleHSS journal : the musculoskeletal journal of Hospital for Special Surgery2008
Case report of spontaneous, nonspinal fractures in a multiple myeloma patient on long-term pamidronate and zoledronic acid.
Article in HSS journal : the musculoskeletal journal of Hospital for Special Surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 43 citations in OpenAlex.
- Atypical Presentation of Multiple Myeloma Affecting Appendicular Skeleton Associated with Pathological Neck of Femur and Proximal Humerus Fractures - A Case Report.Journal of orthopaedic case reports · 2024Article
- Atypical femoral fracture in a multiple myeloma patient undergoing treatment with denosumab: A case report and literature review.International journal of surgery case reports · 2023Article
- Weight-Based Bisphosphonate Administration for Multiple Myeloma Patients and the Risks of Skeletal Complications.Journal of clinical medicine · 2023Article
- Article
- Prevention Of Skeletal Related Events In Multiple Myeloma: Focus On The RANK-L Pathway In The Treatment Of Multiple Myeloma.OncoTargets and therapy · 2019Article
- American Society of Biomechanics Journal of Biomechanics Award 2013: cortical bone tissue mechanical quality and biological mechanisms possibly underlying atypical fractures.Journal of biomechanics · 2015Review
- Spontaneous acetabular periprosthetic fracture in a patient continuously having zoledronic acid.Clinics in orthopedic surgery · 2014Article
- Pathophysiology of atypical femoral fractures and osteonecrosis of the jaw.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2011Review
- Subtrochanteric fracture in a patient receiving zoledronic acid therapy for metastatic breast cancer.Nagoya journal of medical science · 2011Article
- Review
- The role of bisphosphonates in multiple myeloma: mechanisms, side effects, and the future.The oncologist · 2011Review
- Atypical subtrochanteric and femoral shaft fractures and possible association with bisphosphonates.Current osteoporosis reports · 2010Review
- Association of low-energy femoral fractures with prolonged bisphosphonate use: a case--control study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2009Article
- Applying low-intensity pulsed ultrasounds (LIPUS) to a zoledronate-associated atypical femoral shaft fracture without cessation of zoledronate therapy for 3 years follow up: a case report.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal DiseasesArticle
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pamidronate and zoledronic acid are two potent intravenous bisphosphonates used in the treatment of multiple myeloma as well as osteoporosis. While the concern for heightened fracture risk in a patient on long-term bisphosphonate treatment for malignancy has been previously noted, we present the first case of spontaneous, nonspinal fractures in a patient undergoing treatment for multiple myeloma. The patient had a positive 9-year history of bisphosphonate treatment and presented with sequential subtrochanteric stress fractures of the left and right femurs. Pathological reports of fracture site biopsies demonstrate signs consistent with ametabolic bone and no malignancy. These findings point to extreme inhibition of bone turnover by bisphosphonates as the cause of this patient's morbidity. This is a single retrospective case study (level IV evidence).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.