ArticleDevelopment genes and evolution2008
Conservation of linkage and evolution of developmental function within the Tbx2/3/4/5 subfamily of T-box genes: implications for the origin of vertebrate limbs.
Article in Development genes and evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 56 citations in OpenAlex.
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- Pigeon foot feathering reveals conserved limb identity networks.Developmental biology · 2019Article
- Genome Sequencing of the Japanese Eel (Marine drugs · 2019Article
- Epigenetic Suppression of the T-box Subfamily 2 (International journal of molecular sciences · 2019Article
- Overexpression of TBX3 transcription factor as a potential diagnostic marker for breast cancer.Molecular and clinical oncology · 2019Article
- Inference of the ancestral vertebrate phenotype through vestiges of the whole-genome duplications.Briefings in functional genomics · 2018Review
- Transcriptomic Alterations in Lung Adenocarcinoma Unveil New Mechanisms Targeted by theFrontiers in oncology · 2018Article
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- Similarity of morphological composition and developmental patterning in paired fins of the elephant shark.Scientific reports · 2017Article
- TBX2 over-expression promotes nasopharyngeal cancer cell proliferation and invasion.Oncotarget · 2017Article
- T-box family of transcription factor-TBX5, insights in development and disease.American journal of translational research · 2017Article
- Regulatory evolution of Tbx5 and the origin of paired appendages.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Developmental Mechanism of Limb Field Specification along the Anterior-Posterior Axis during Vertebrate Evolution.Journal of developmental biology · 2016Review
- Molecular shifts in limb identity underlie development of feathered feet in two domestic avian species.eLife · 2016Article
- The T-box gene family: emerging roles in development, stem cells and cancer.Development (Cambridge, England) · 2014Review
- Connectivity of vertebrate genomes: Paired-related homeobox (Prrx) genes in spotted gar, basal teleosts, and tetrapods.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2014Article
- Body wall development in lamprey and a new perspective on the origin of vertebrate paired fins.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Tbx2/3 is an essential mediator within the Brachyury gene network during Ciona notochord development.Development (Cambridge, England) · 2013Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
T-box genes encode a family of DNA-binding transcription factors implicated in numerous developmental processes in all metazoans. The Tbx2/3/4/5 subfamily genes are especially interesting because of their key roles in the evolution of vertebrate appendages, eyes, and the heart, and, like the Hox genes, the longevity of their chromosomal linkage. A BAC library derived from the single male amphioxus (Branchiostoma floridae) used to sequence the amphioxus genome was screened for AmphiTbx2/3 and AmphiTbx4/5, yielding two independent clones containing both genes. Using comparative expression, genomic linkage, and phylogenetic analyses, we have reconstructed the evolutionary histories of these members of the T-box gene family. We find that the Tbx2-Tbx4 and Tbx3-Tbx5 gene pairs have maintained tight linkage in most animal lineages since their birth by tandem duplication, long before the divergence of protostomes and deuterostomes (e.g., arthropods and vertebrates) at least 600 million years ago, and possibly before the divergence of poriferans and cnidarians (e.g., sponges and jellyfish). Interestingly, we find that the gene linkage detected in all vertebrate genomes has been maintained in the primitively appendage-lacking, basal chordate, amphioxus. Although all four genes have been involved in the evolution of developmental programs regulating paired fin and (later) limb outgrowth and patterning, and most are also implicated in eye and heart development, linkage maintenance--often considered due to regulatory constraints imposed by limb, eye, and/or heart associated gene expression--is undoubtedly a consequence of other, much more ancient functional constraints.
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