ArticleEuropean journal of applied physiology2009
Short-term hypoxia reduces arterial stiffness in healthy men.
Article in European journal of applied physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Effects of Intermittent Normobaric Hypoxia on Health-Related Outcomes in Healthy Older Adults: A Systematic Review.Sports medicine - open · 2023Pooled it
- Effects of Intermittent Hypoxia-Hyperoxia on Performance- and Health-Related Outcomes in Humans: A Systematic Review.Sports medicine - open · 2022Pooled it
- Effects of an Acute Pilates Program under Hypoxic Conditions on Vascular Endothelial Function in Pilates Participants: A Randomized Crossover Trial.International journal of environmental research and public health · 2020Trial
- Chemoreflex function in pulmonary diseases - A review.The Journal of physiology · 2025Review
- Effects of Heat and Hypoxia Training on the Fat Oxidation Capacity of Competitive Athletes.European journal of sport science · 2025Article
- Inter-individual variation in SpOPhysiological reports · 2025Article
- Hypoxic Therapy as a New Therapeutic Modality for Cardiovascular Benefit: A Mini Review.Reviews in cardiovascular medicine · 2022Review
- Intermittent Hypoxia as a Therapeutic Tool to Improve Health Parameters in Older Adults.International journal of environmental research and public health · 2022Article
- Influence of acute and chronic intermittent hypoxic-hyperoxic exposure prior to aerobic exercise on cardiovascular risk factors in geriatric patients-a randomized controlled trial.Frontiers in physiology · 2022Article
- Effects of Intermittent Hypoxia-Hyperoxia Exposure Prior to Aerobic Cycling Exercise on Physical and Cognitive Performance in Geriatric Patients-A Randomized Controlled Trial.Frontiers in physiology · 2022Article
- The effect of intermittent hypoxia training on migraine: a randomized controlled trial.American journal of translational research · 2020Article
- Comparison of the Effectiveness of High-Intensity Interval Training in Hypoxia and Normoxia in Healthy Male Volunteers: A Pilot Study.BioMed research international · 2019Article
- Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population.Physiological genomics · 2018Article
- Therapeutic Use of Exercising in Hypoxia: Promises and Limitations.Frontiers in physiology · 2016Article
- Chemosensitivity, Cardiovascular Risk, and the Ventilatory Response to Exercise in COPD.PloS one · 2016Article
- Hypoxic Conditioning as a New Therapeutic Modality.Frontiers in pediatrics · 2015Review
- Effect of hypoxic training on inflammatory and metabolic risk factors: a crossover study in healthy subjects.Physiological reports · 2014Article
- Successive exposure to moderate hypoxia does not affect glucose metabolism and substrate oxidation in young healthy men.SpringerPlus · 2014Article
- Vascular adaptations to hypobaric hypoxic training in postmenopausal women.The journal of physiological sciences : JPS · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examined the effects of hypoxia (80% arterial oxyhaemoglobin saturation for 20 min) and the accompanying changes in heart rate and blood pressure on two components of arterial stiffness in healthy men. Augmentation index (AIx) and time to reflection (Tr) representing measures of muscular artery and aortic stiffness, respectively, were continuously measured. At first, subjects were exposed to either hypoxia (n = 12) or room air (n = 5). During early hypoxia AIx increased by 6% before decreasing to baseline. After hypoxia AIx decreased by a further 6%. In contrast there was no change in Tr. Six subjects were then exposed to hypoxia following infusion with the nitric oxide (NO) synthase inhibitor NG-mono-methyl-L: -arginine (L-NMMA) or saline. During hypoxia AIx decreased by 12% following saline but increased by 14% after L-NMMA and Tr did not change. These findings suggest that hypoxia may induce NO-mediated vasodilatation of small muscular arteries but not the aorta.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.