ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2009
Cerebrospinal fluid levels of interleukin-6 and interleukin-12 in children with meningitis.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 32 citations in OpenAlex.
- Interleukin-6 as a sepsis biomarker in neonatal and pediatric care: A retrospective real world cohort study.European journal of pediatrics · 2026Article
- Diagnostic Utility of Cerebrospinal Fluid White Blood Cell Components for the Identification of Bacterial Meningitis in Infants.Journal of the Pediatric Infectious Diseases Society · 2023Article
- Toll-like receptor linked cytokine profiles in cerebrospinal fluid discriminate neurological infection from sterile inflammation.Brain communications · 2020Article
- Neonatal Meningitis: Overcoming Challenges in Diagnosis, Prognosis, and Treatment with Omics.Frontiers in pediatrics · 2017Review
- Cerebrospinal fluid cytokines in the diagnosis of bacterial meningitis in infants.Pediatric research · 2016Article
- Diagnostic performance of interleukin-6 and interleukin-8 for bacterial meningitis: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Brain-derived neurotrophic factor and interleukin-6 levels in the serum and cerebrospinal fluid of children with viral infection-induced encephalopathy.Neurochemical research · 2014Article
- Amoxicillin-induced aseptic meningoencephalitis.International journal of general medicine · 2010Article
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Authors and funding
6 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeCertain cytokines play important roles in the pathophysiology of meningitis. The main purpose of this study was to investigate if the levels of interleukin-6 (IL-6) and interleukin-12 (IL-12) in cerebrospinal fluid (CSF) could be diagnostic predictors of bacterial meningitis in children.
methodsCSF was obtained from 95 patients suspected with meningitis. These cases were classified to the bacterial meningitis (n = 12), aseptic meningitis (n = 41), and nonmeningitis (n = 42) groups. The levels of IL-6 and IL-12 in CSF were measured using the enzyme-linked immmunosorbent assays test.
resultsThe CSF IL-6 levels in the bacterial meningitis group (45.2 +/- 50.0 pg/ml) were significantly higher than those in the aseptic meningitis group (12.9 +/- 10.2 pg/ml) and the nonmeningitis group (6.5 +/- 7.8 pg/ml; p < 0.05). The CSF IL-12 levels in the bacterial meningitis group (69.8 +/- 67.1 pg/ml) were significantly higher than those in the aseptic meningitis group (22.9 +/- 10.8 pg/ml) and the nonmeningitis group (15.3 +/- 11.2 pg/ml; p < 0.05). With regard to diagnosis, the measurement of CSF IL-6 and IL-12 levels showed sensitivities of 96% and 96%, respectively, and specificities of 51% and 75%, respectively.
conclusionIt is suggested that the CSF IL-6 and IL-12 levels are useful markers for distinguishing bacterial meningitis from aseptic meningitis.
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