Trial reportPsychopharmacology2009
Positive effects of nicotine on cognition: the deployment of attention for prospective memory.
Trial report in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of the acute effects of nicotine and smoking on human performance.Psychopharmacology · 2010Pooled it
- Effect of varenicline on aspects of inhibitory control in smokers.Psychopharmacology · 2014Trial
- Prompt but inefficient: nicotine differentially modulates discrete components of attention.Psychopharmacology · 2011Trial
- Modafinil improves rapid shifts of attention.Psychopharmacology · 2009Trial
- The Intention to React to Sounds Induces Sleep Disturbances and Alters Brain Responses to Sounds during Sleep: A Pilot Study.Clocks & sleep · 2022Article
- Metabolic Syndrome Associated with Tobacco and Caffeine Products Use Among Refugee Adolescents: Risk of Dyslipidemia.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Cognitive performance effects of nicotine and industry affiliation: a systematic review.Substance abuse : research and treatment · 2020Article
- Rapid eye movement sleep mediates age-related decline in prospective memory consolidation.Sleep · 2019Article
- The Effects of Nicotine and Tobacco Use on Brain Reward Function: Interaction With Nicotine Dependence Severity.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Article
- Nicotine increases anterior insula activation to expected and unexpected outcomes among nonsmokers.Psychopharmacology · 2017Article
- Article
- Association between smoking and cognitive impairment in multiple sclerosis.Neuropsychiatric disease and treatment · 2014Article
- Cognition as a therapeutic target in late-life depression: potential for nicotinic therapeutics.Biochemical pharmacology · 2013Review
- Nicotine derived from the electronic cigarette improves time-based prospective memory in abstinent smokers.Psychopharmacology · 2013Article
- APOE E4 Carriers show prospective memory enhancement under nicotine, and evidence for specialisation within medial BA10.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Improvement of attentional function with antagonism of nicotinic receptors in female rats.European journal of pharmacology · 2013Article
- Leveraging the cortical cholinergic system to enhance attention.Neuropharmacology · 2013Review
- Functional brain imaging of nicotinic effects on higher cognitive processes.Biochemical pharmacology · 2011Review
- Chronic smoking, but not acute nicotine administration, modulates neural correlates of working memory.Psychopharmacology · 2011Article
- Positive effects of cholinergic stimulation favor young APOE epsilon4 carriers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleHuman and animal studies over the last two decades report that nicotine can improve cognitive performance. Prospective memory (PM), the retrieval and implementation of a previously encoded intention, is also improved by pre-administration of nicotine. As with other nicotine effects, however, predicting precisely how and when nicotine improves the processes engaged by PM has proved less straightforward.
objectiveWe present two studies that explore the source of nicotine's enhancement of PM. Experiment 1 tests for effects of nicotine on preparatory attention (PA) for PM target detection. Experiment 2 asks whether nicotine enhances processing of the perceptual attributes of the PM targets. MATERIALS AND
methodsYoung adult non-smokers matched on baseline performance measures received either 1 mg nicotine or matched placebo via nasal spray. Volunteers completed novel PM tasks at 15 min post-administration.
resultsExperiment 1 confirmed that pre-administration of nicotine to non-smokers improved detection rate for prospective memory targets presented during an attention-demanding ongoing task. There was no relationship between PM performance and measures of preparatory attention. In experiment 2, salient targets were more likely to be detected than non-salient targets, but nicotine did not confer any additional advantage to salient targets.
conclusionThe present study suggests that nicotinic stimulation does not work to enhance perceptual salience of target stimuli (experiment 2), nor does it work through better deployment of preparatory working attention (experiment 1). An alternative explanation that nicotine promotes PM detection by facilitating disengagement from the ongoing task is suggested as a future line of investigation.
Indexed as
Identifiers
18815772What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.