ReviewImmunologic research2008
X-linked lymphoproliferative disease (XLP): a model of impaired anti-viral, anti-tumor and humoral immune responses.
Review in Immunologic research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Genetics of Primary Hemophagocytic Lymphohistiocytosis.Advances in experimental medicine and biology · 2024Review
- Asymptomatic incidental neuroblastoma in a patient with SH2D1A deficiency.Pediatric blood & cancer · 2022Article
- FOXP3 protects conventional human T cells from premature restimulation-induced cell death.Cellular & molecular immunology · 2021Article
- Fatty Acid Synthase Contributes to Restimulation-Induced Cell Death of Human CD4 T Cells.Frontiers in molecular biosciences · 2019Article
- What is infectiveness and how is it involved in infection and immunity?BMC immunology · 2015Review
- EBV Persistence--Introducing the Virus.Current topics in microbiology and immunology · 2015Review
- Article
- Primary immunodeficiency diseases worldwide: more common than generally thought.Journal of clinical immunology · 2013Article
- Article
- Pyrosequencing allows the detection of emergent ganciclovir resistance mutations after HCMV infection.Medical microbiology and immunology · 2011Article
- The power and the promise of restimulation-induced cell death in human immune diseases.Immunological reviews · 2010Review
- SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions.Seminars in immunopathology · 2010Review
- Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency.The Journal of clinical investigation · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major focus of our research is to understand the molecular and cellular basis of X-linked lymphoproliferative disease (XLP), a rare and often fatal immunodeficiency caused by mutations in the SH2D1A gene, which encodes the adaptor molecule SAP. Recently, we observed that SAP is essential for the development of natural killer T (NKT) cells, a lymphocyte population that participates in protection against certain tumors, infections, and autoimmune states. In this review, we describe the approaches that we are taking to understand the role of SAP in immune cells, including NKT cells. By using SAP as the focal point of our studies, we hope to identify novel signaling pathways that could be targeted to improve the treatment for patients with XLP as well as more common disorders, such as autoimmunity and cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.