ArticlePloS one2008
Species specificity in major urinary proteins by parallel evolution.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
80 citing papers in PubMed, 161 citations in OpenAlex.
- Major urinary protein 1 modulates neuronal excitability in the medial prefrontal cortex in a male mouse model of affective empathy.Nature communications · 2026Article
- Article
- Proteomic and phosphoproteomic signatures of aging mouse liver.GeroScience · 2025Article
- Behavioral Assays in the Study of Olfaction.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Type 2 vomeronasal receptor-A4 subfamily: Potential predator sensors in mice.Genesis (New York, N.Y. : 2000) · 2024Review
- Major urinary protein (Microbiology spectrum · 2024Article
- Proteomic and phosphoproteomic characterization of cardiovascular tissues after long term exposure to simulated space radiation.Frontiers in physiology · 2024Article
- The Expansion of House Mouse Major Urinary Protein Genes Likely Did Not Facilitate Commensalism with Humans.Genes · 2023Article
- Sex-biased gene expression across mammalian organ development and evolution.Science (New York, N.Y.) · 2023Article
- Increased paternal corticosterone exposure influences offspring behaviour and expression of urinary pheromones.BMC biology · 2023Article
- Urinary Proteins of Female Domestic Dog (Veterinary sciences · 2023Article
- Infection withAnimals : an open access journal from MDPI · 2023Article
- The major urinary protein gene cluster knockout mouse as a novel model for translational metabolism research.Scientific reports · 2022Article
- Regulation of Sexually Dimorphic Expression of Major Urinary Proteins.Frontiers in physiology · 2022Review
- Urinary protein analysis in mice lacking major urinary proteins.Experimental animals · 2021Article
- Neural and Hormonal Basis of Opposite-Sex Preference by Chemosensory Signals.International journal of molecular sciences · 2021Review
- Biological Roles of Lipocalins in Chemical Communication, Reproduction, and Regulation of Microbiota.Frontiers in physiology · 2021Review
- Coding of pheromones by vomeronasal receptors.Cell and tissue research · 2021Review
- Vulpeculin: a novel and abundant lipocalin in the urine of the common brushtail possum,Open biology · 2020Article
- In Contrast to Dietary Restriction, Application of Resveratrol in Mice Does not Alter Mouse Major Urinary Protein Expression.Nutrients · 2020Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Species-specific chemosignals, pheromones, regulate social behaviors such as aggression, mating, pup-suckling, territory establishment, and dominance. The identity of these cues remains mostly undetermined and few mammalian pheromones have been identified. Genetically-encoded pheromones are expected to exhibit several different mechanisms for coding 1) diversity, to enable the signaling of multiple behaviors, 2) dynamic regulation, to indicate age and dominance, and 3) species-specificity. Recently, the major urinary proteins (Mups) have been shown to function themselves as genetically-encoded pheromones to regulate species-specific behavior. Mups are multiple highly related proteins expressed in combinatorial patterns that differ between individuals, gender, and age; which are sufficient to fulfill the first two criteria. We have now characterized and fully annotated the mouse Mup gene content in detail. This has enabled us to further analyze the extent of Mup coding diversity and determine their potential to encode species-specific cues.Our results show that the mouse Mup gene cluster is composed of two subgroups: an older, more divergent class of genes and pseudogenes, and a second class with high sequence identity formed by recent sequential duplications of a single gene/pseudogene pair. Previous work suggests that truncated Mup pseudogenes may encode a family of functional hexapeptides with the potential for pheromone activity. Sequence comparison, however, reveals that they have limited coding potential. Similar analyses of nine other completed genomes find Mup gene expansions in divergent lineages, including those of rat, horse and grey mouse lemur, occurring independently from a single ancestral Mup present in other placental mammals. Our findings illustrate that increasing genomic complexity of the Mup gene family is not evolutionarily isolated, but is instead a recurring mechanism of generating coding diversity consistent with a species-specific function in mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.