ArticleNature2008
Activity-dependent regulation of inhibitory synapse development by Npas4.
Article in Nature, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 387 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
387 citing papers in PubMed, 643 citations in OpenAlex.
- Interneurons and network activity in the cerebral cortex: a developmental dialogue.Nature reviews. Neuroscience · 2026Review
- Aging disrupts transcriptional programs for memory updating in the dorsal hippocampus and reveals a required role forbioRxiv : the preprint server for biology · 2026Article
- Sleep Deprivation and Neuronal Hyperexcitation Share Transcriptomic Signatures.Neuropsychopharmacology reports · 2026Article
- Crosstalk Between Cortical Plasticity and Peripheral Nervous Injury: Insights, Mechanisms, and Future Directions.CNS neuroscience & therapeutics · 2026Review
- Neuronal activity-driven 3D chromatin dynamics in cortical pyramidal neurons depend on SATB2.Nucleic acids research · 2026Article
- Cocaine Hijacks the Npas4-dependent Somatostatin Ensembles in the mPFC to Mediate Attention.Neuroscience bulletin · 2026Article
- Maternal Isocaloric Monosaccharide Diets Reorganize Dorsal-Ventral Hippocampal Maturation and Ventral Plasticity in Rat Offspring.Cellular and molecular neurobiology · 2026Article
- The intrinsic excitability of and autophagy protein expression levels in dentate gyrus ensembles regulate fear generalization.Neural regeneration research · 2026Article
- Disruption of psychostimulant-associated memories by single, low dose ketamine in rats.Neuropharmacology · 2026Article
- Review
- Article
- Npas4 is involved in synaptic and cognitive function by regulating the transcription of Neuroligin-1 and N-cadherin.Translational psychiatry · 2026Article
- Npas4 regulates synaptic development in the patch/striosome compartment and early affective vocalization in neonatal mice.Molecular brain · 2026Article
- Article
- Epigenetic and Neurogenomic Mechanisms Linking Physical Activity to Brain Plasticity and Cognitive Function.Genes · 2026Review
- NPAS4 refines spatial and temporal firing in CA1 pyramidal neurons.bioRxiv : the preprint server for biology · 2026Article
- Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation.Journal of neurochemistry · 2026Review
- Modeling epilepsy by loss-of-function of the CUG-binding protein Elav-like family member 2 in zebrafish with multi-omics analysis.Chinese medical journal · 2026Article
- Single-cell Multiome Analysis of Chromatin State and Transcriptome in the Human Basal Ganglia.bioRxiv : the preprint server for biology · 2026Article
- Deletion of NPAS4 in olfactory bulb principal neurons alters E/I balance and impairs decoding of chemically similar odour molecules.The Journal of physiology · 2026Article
327 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Neuronal activity regulates the development and maturation of excitatory and inhibitory synapses in the mammalian brain. Several recent studies have identified signalling networks within neurons that control excitatory synapse development. However, less is known about the molecular mechanisms that regulate the activity-dependent development of GABA (gamma-aminobutyric acid)-releasing inhibitory synapses. Here we report the identification of a transcription factor, Npas4, that plays a role in the development of inhibitory synapses by regulating the expression of activity-dependent genes, which in turn control the number of GABA-releasing synapses that form on excitatory neurons. These findings demonstrate that the activity-dependent gene program regulates inhibitory synapse development, and suggest a new role for this program in controlling the homeostatic balance between synaptic excitation and inhibition.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.