ArticleProceedings of the National Academy of Sciences of the United States of America2008
Role of selection in the emergence of lineages and the evolution of virulence in Neisseria meningitidis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 1 synthesis or guideline pooled it, 136 citations in OpenAlex.
- The elusive meningococcal meningitis serogroup: a systematic review of serogroup B epidemiology.BMC infectious diseases · 2010Pooled it
- Emergence of short-lived meningococci causing focal epidemics can be associated with gene transfer from carriage-associatedbioRxiv : the preprint server for biology · 2026Article
- Epistasis mediates the role of negative frequency-dependent selection in bacterial strain structure.PLoS computational biology · 2026Article
- Genotypic and phenotypic comparison of Neisseria meningitidis carriage and invasive disease isolates contemporaneously collected in the Netherlands.FEMS microbiology letters · 2026Article
- Genetic population structure of Haemophilus influenzae at local and global scales.Nature microbiology · 2025Article
- Article
- Genetic and Antigenic Diversity ofPathogens (Basel, Switzerland) · 2025Article
- Review
- Darwin review: the evolution of virulence in human pathogens.Proceedings. Biological sciences · 2024Review
- Microevolution and Its Impact on Hypervirulence, Antimicrobial Resistance, and Vaccine Escape inMicroorganisms · 2023Review
- Dynamics of parasite growth in genetically diverse Plasmodium falciparum isolates.Molecular and biochemical parasitology · 2023Article
- Signatures of selection in core and accessory genomes indicate different ecological drivers of diversification among Bacillus cereus clades.Molecular ecology · 2022Article
- Evaluating the Impact of Meningococcal Vaccines With Synthetic Controls.American journal of epidemiology · 2022Article
- The roles of antimicrobial resistance, phage diversity, isolation source and selection in shaping the genomic architecture ofMicrobial genomics · 2021Article
- Negative frequency-dependent selection and asymmetrical transformation stabilise multi-strain bacterial population structures.The ISME journal · 2021Article
- An antigenic diversification threshold for falciparum malaria transmission at high endemicity.PLoS computational biology · 2021Article
- Recent advances in understanding and combattingFaculty reviews · 2021Review
- Diversification in immunogenicity genes caused by selective pressures in invasive meningococci.Microbial genomics · 2020Article
- Persistence Dynamics of Antimicrobial-ResistantAntimicrobial agents and chemotherapy · 2020Article
- Epidemiological consequences of enduring strain-specific immunity requiring repeated episodes of infection.PLoS computational biology · 2020Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Neisseria meningitis is a human commensal bacterium that occasionally causes life-threatening disease. As with a number of other bacterial pathogens, meningococcal populations comprise distinct lineages, which persist over many decades and during global spread in the face of high rates of recombination. In addition, the propensity to cause invasive disease is associated with particular "hyperinvasive" lineages that coexist with less invasive lineages despite the fact that disease does not contribute to host-to-host transmission. Here, by combining a modeling approach with molecular epidemiological data from 1,108 meningococci isolated in the Czech Republic over 27 years, we show that interstrain competition, mediated by immune selection, can explain both the persistence of multiple discrete meningococcal lineages and the association of a subset of these with invasive disease. The model indicates that the combinations of allelic variants of housekeeping genes that define these lineages are associated with very small differences in transmission efficiency among hosts. These findings have general implications for the emergence of lineage structure and virulence in recombining bacterial populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.