ArticleProceedings of the National Academy of Sciences of the United States of America2008
Salmonella pathogenesis reveals that BMP signaling regulates blood cell homeostasis and immune responses in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Differential Expression of Immune Genes between Two Closely Related Beetle Species with Different Immunocompetence following Attack by Asecodes parviclava.Genome biology and evolution · 2020Article
- The PAX-SIX-EYA-DACH network modulates GATA-FOG function in fly hematopoiesis and human erythropoiesis.Development (Cambridge, England) · 2020Article
- TGFβ/BMP immune signaling affects abundance and function of C. elegans gut commensals.Nature communications · 2019Article
- Hedgehog signaling from the Posterior Signaling Center maintains U-shaped expression and a prohemocyte population in Drosophila.Developmental biology · 2018Article
- Article
- Functional Conservation of the Glide/Gcm Regulatory Network Controlling Glia, Hemocyte, and Tendon Cell Differentiation in Drosophila.Genetics · 2016Article
- MANF silencing, immunity induction or autophagy trigger an unusual cell type in metamorphosing Drosophila brain.Cellular and molecular life sciences : CMLS · 2015Article
- Antioxidants maintain E-cadherin levels to limit Drosophila prohemocyte differentiation.PloS one · 2014Article
- Characterization of the TGF-β1 signaling abnormalities in the Gata1low mouse model of myelofibrosis.Blood · 2013Article
- Signal transduction pathways, intrinsic regulators, and the control of cell fate choice.Biochimica et biophysica acta · 2013Review
- Drosophila E-cadherin functions in hematopoietic progenitors to maintain multipotency and block differentiation.PloS one · 2013Article
- Size control of the Drosophila hematopoietic niche by bone morphogenetic protein signaling reveals parallels with mammals.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Odd-skipped maintains prohemocyte potency and blocks blood cell development in Drosophila.Genesis (New York, N.Y. : 2000) · 2011Article
- Host and pathogen glycosaminoglycan-binding proteins modulate antimicrobial peptide responses in Drosophila melanogaster.Infection and immunity · 2011Article
- Article
- An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis.BMC developmental biology · 2010Article
- Upregulation of the Drosophila Friend of GATA gene U-shaped by JAK/STAT signaling maintains lymph gland prohemocyte potency.Molecular and cellular biology · 2009Article
- Characterization of a lamellocyte transcriptional enhancer located within the misshapen gene of Drosophila melanogaster.PloS one · 2009Article
- Drosophila embryos as model systems for monitoring bacterial infection in real time.PLoS pathogens · 2009Article
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5 authors at 2 institutions in 1 country.
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Abstract
Intercellular signaling by bone morphogenetic proteins (BMPs) regulates developmental decisions in virtually all animals. Here, we report that Decapentaplegic (Dpp; a Drosophila BMP family member) plays a role in blood cell homeostasis and immune responses by regulating a transcription factor cascade. The cascade begins with Dpp repression of Zfh1, continues with Zfh1 activation of Serpent (Srp; a GATA factor), and terminates with Srp activation of U-shaped (Ush) in hematopoietic cells. Hyperactivation of Zfh1, Srp, and Ush in dpp mutants leads to hyperplasia of plasmatocytes. Salmonella challenge revealed that in dpp mutants the misregulation of this cascade also prevents the generation of lamellocytes. These findings support the hypothesis that Ush participates in a switch between plasmatocyte and lamellocyte fate in a common precursor and further suggests a mechanism for how all blood cell types can arise from a single progenitor. These results also demonstrate that combining Drosophila and Salmonella genetics can provide novel opportunities for advancing our knowledge of hematopoiesis and innate immunity.
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