ArticleProceedings of the National Academy of Sciences of the United States of America2008
Distinct size distribution of endogeneous siRNAs in maize: Evidence from deep sequencing in the mop1-1 mutant.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
112 citing papers in PubMed, 202 citations in OpenAlex.
- Article
- The epigenetic landscape of heterosis: integrating multi-layer regulatory insights and navigating the path to causality.Frontiers in plant science · 2026Review
- mop1 affects maize recombination landscapes by modulating methylation of MITEs near genes in open chromatin.Nature communications · 2025Article
- Empowering plant epigenetics to breed resilience of crops: From nucleolar dominance to transgenerational epigenetic inheritance.The plant genome · 2025Review
- Transgenerational epigenetic inheritance during plant evolution and breeding.Trends in plant science · 2024Review
- Detection of exogenous siRNA inside sweet corn bundle sheath cells and the RNAi dynamics in the early stage ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- RNA-directed DNA methylation mutants reduce histone methylation at the paramutated maize booster1 enhancer.Plant physiology · 2024Article
- Heritable changes of epialleles near genes in maize can be triggered in the absence of CHH methylation.Plant physiology · 2024Article
- Epigenetic Regulation in Heterosis and Environmental Stress: The Challenge of Producing Hybrid Epigenomes to Face Climate Change.Epigenomes · 2023Review
- RDR2 in maize: one-way road to double-stranded RNA.The Plant cell · 2022Article
- Small RNAs mediate transgenerational inheritance of genome-wide trans-acting epialleles in maize.Genome biology · 2022Article
- Reinforcement of CHH methylation through RNA-directed DNA methylation ensures sexual reproduction in rice.Plant physiology · 2022Article
- Article
- You shall not pass! A Chromatin barrier story in plants.Frontiers in plant science · 2022Review
- Non-Coding RNAs in Response to Drought Stress.International journal of molecular sciences · 2021Review
- Atypical DNA methylation, sRNA-size distribution, and female gametogenesis in Utricularia gibba.Scientific reports · 2021Article
- Chromosome-level genome assembly of a regenerable maize inbred line A188.Genome biology · 2021Article
- RNA-directed DNA methylation prevents rapid and heritable reversal of transposon silencing under heat stress in Zea mays.PLoS genetics · 2021Article
- Reproductive phasiRNA loci and DICER-LIKE5, but not microRNA loci, diversified in monocotyledonous plants.Plant physiology · 2021Article
- TheProceedings of the National Academy of Sciences of the United States of America · 2021Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
Small RNAs from plants are known to be highly complex and abundant, with this complexity proportional to genome size. Most endogenous siRNAs in Arabidopsis are dependent on RNA-DEPENDENT RNA POLYMERASE 2 (RDR2) for their biogenesis. Recent work has demonstrated that the maize MEDIATOR OF PARAMUTATION1 (mop1) gene is a predicted ortholog of RDR2. The mop1 gene is required for establishment of paramutation and maintenance of transcriptional silencing of transposons and transgenes, suggesting the potential involvement of small RNAs. We analyzed small RNAs in wild-type maize and in the isogenic mop1-1 loss-of-function mutant by using Illumina's sequencing-by-synthesis (SBS) technology, which allowed us to characterize the complement of maize small RNAs to considerable depth. Similar to rdr2 in Arabidopsis, in mop1-1, the 24-nucleotide (nt) endogenous heterochromatic short-interfering siRNAs were dramatically reduced, resulting in an enrichment of miRNAs and transacting siRNAs. In contrast to the Arabidopsis rdr2 mutant, the mop1-1 plants retained a highly abundant heterochromatic approximately 22-nt class of small RNAs, suggesting a second mechanism for heterochromatic siRNA production. The enrichment of miRNAs and loss of 24-nt heterochromatic siRNAs in mop1-1 should be advantageous for miRNA discovery as the maize genome becomes more fully sequenced.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.