ArticleBlood2009
Distinct roles of helper T-cell subsets in a systemic autoimmune disease.
Article in Blood, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Article
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- CD8 follicular T cells localize throughout the follicle during germinal center reactions and maintain cytolytic and helper properties.Journal of autoimmunity · 2021Article
- Integrative computational approach identifies drug targets in CD4NPJ systems biology and applications · 2021Article
- T cell signaling and Treg dysfunction correlate to disease kinetics in IL-2Rα-KO autoimmune mice.Scientific reports · 2020Article
- Exploring celiac disease candidate pathways by global gene expression profiling and gene network cluster analysis.Scientific reports · 2020Article
- Angelica sinensis polysaccharide prevents mitochondrial apoptosis by regulating the Treg/Th17 ratio in aplastic anemia.BMC complementary medicine and therapies · 2020Article
- New Insights in the Pathogenesis and Therapy of Cold Agglutinin-Mediated Autoimmune Hemolytic Anemia.Frontiers in immunology · 2020Review
- IL-12-Induced Immune Suppressive Deficit During CD8+ T-Cell Differentiation.Frontiers in immunology · 2020Article
- Teaching an old dog new tricks: next-generation CAR T cells.British journal of cancer · 2019Review
- CD8 Follicular T Cells Promote B Cell Antibody Class Switch in Autoimmune Disease.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Mice with double knockout of H2-Eb1 and H2-Ab1 exhibit reduced susceptibility to allergic rhinitis.PloS one · 2018Article
- Article
- CD8Journal of autoimmunity · 2016Article
- Steroid Refractory Autoimmune Haemolytic Anaemia Secondary to Sarcoidosis Successfully Treated with Rituximab and Mycophenolate Mofetil.Case reports in hematology · 2016Article
- IL-33 reflects dynamics of disease activity in patients with autoimmune hemolytic anemia by regulating autoantibody production.Journal of translational medicine · 2015Article
- CXCL13, CCL4, and sTNFR as circulating inflammatory cytokine markers in primary and SLE-related autoimmune hemolytic anemia.Journal of translational medicine · 2015Article
- Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210.Nature immunology · 2014Article
- Partial tolerance of autoreactive B and T cells to erythrocyte-specific self-antigens in mice.Haematologica · 2012Article
- Production of the effector cytokine interleukin-17, rather than interferon-γ, is more strongly associated with autoimmune hemolytic anemia.Haematologica · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Imbalance of T-helper cell (Th) differentiation and subsequent cytokine dysregulation is implicated in inflammatory and autoimmune diseases. In particular, 2 cytokines produced by different Th cell populations, interferon-gamma (IFN-gamma) and interleukin-17 (IL-17), have been shown to play a critical role in autoimmunity. We have examined the roles of these cytokines in a mouse model of systemic autoimmunity resulting from the deletion of IL-2 in which autoimmune hemolytic anemia (AIHA) is a prominent feature. We demonstrate that, in IL-2-knockout (KO) BALB/c mice, elimination of the Th1 cytokine, IFN-gamma, delays the development of AIHA. Further, CD4(+) T cells from IL-2/IFN-gamma-KO mice produce elevated levels of IL-17 compared with wild-type (WT) and IL-2-KO, and these mice eventually develop intestinal inflammation. In contrast, elimination of the Th17 cytokine, IL-17, from IL-2-KO mice fails to suppress early acute AIHA development. These results suggest that in a systemic autoimmune disease with multiple manifestations, Th1 cells drive the early autoantibody response and IL-17-producing cells may be responsible for the more chronic tissue inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.