ArticleMolecular biology of the cell2008
Posttranslational regulation of NF-YA modulates NF-Y transcriptional activity.
Article in Molecular biology of the cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Article
- Analysis of amino acid residues affecting the transcriptional activity of nuclear factor Ya.Molecular biology research communications · 2026Article
- NF-YAl drives EMT in ClaudinCell death & disease · 2023Article
- Combined role for YAP-TEAD and YAP-RUNX2 signalling in substrate-stiffness regulation of cardiac fibroblast proliferation.Biochimica et biophysica acta. Molecular cell research · 2022Article
- NIPK, a protein pseudokinase that interacts with the C subunit of the transcription factor NF-Y, is involved in rhizobial infection and nodule organogenesis.Frontiers in plant science · 2022Article
- MITO-Luc/GFP zebrafish model to assess spatial and temporal evolution of cell proliferation in vivo.Scientific reports · 2021Article
- Overexpression and alternative splicing of NF-YA in breast cancer.Scientific reports · 2019Article
- Regulation of hepatic gluconeogenesis by nuclear factor Y transcription factor in mice.The Journal of biological chemistry · 2018Article
- Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model.Oncotarget · 2017Article
- Prognostic role of NF-YA splicing isoforms and Lamin A status in low grade endometrial cancer.Oncotarget · 2017Article
- The laminA/NF-Y protein complex reveals an unknown transcriptional mechanism on cell proliferation.Oncotarget · 2017Article
- Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.The Journal of biological chemistry · 2015Article
- Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit.Nature communications · 2014Article
- Transcriptional activation of PRMT5 by NF-Y is required for cell growth and negatively regulated by the PKC/c-Fos signaling in prostate cancer cells.Biochimica et biophysica acta · 2014Article
- Gene Family Analysis of thePlant molecular biology reporter · 2014Article
- Arabidopsis defense against Botrytis cinerea: chronology and regulation deciphered by high-resolution temporal transcriptomic analysis.The Plant cell · 2012Article
- Molecular imaging of nuclear factor-Y transcriptional activity maps proliferation sites in live animals.Molecular biology of the cell · 2012Article
- Article
- The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters.The EMBO journal · 2011Article
- The long reach of noncoding RNAs.Nature genetics · 2011Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NF-Y binds to CCAAT motifs in the promoter region of a variety of genes involved in cell cycle progression. The NF-Y complex comprises three subunits, NF-YA, -YB, and -YC, all required for DNA binding. Expression of NF-YA fluctuates during the cell cycle and is down-regulated in postmitotic cells, indicating its role as the regulatory subunit of the complex. Control of NF-YA accumulation is posttranscriptional, NF-YA mRNA being relatively constant. Here we show that the levels of NF-YA protein are regulated posttranslationally by ubiquitylation and acetylation. A NF-YA protein carrying four mutated lysines in the C-terminal domain is more stable than the wild-type form, indicating that these lysines are ubiquitylated Two of the lysines are acetylated in vitro by p300, suggesting a competition between ubiquitylation and acetylation of overlapping residues. Interestingly, overexpression of a degradation-resistant NF-YA protein leads to sustained expression of mitotic cyclin complexes and increased cell proliferation, indicating that a tight regulation of NF-YA levels contributes to regulate NF-Y activity.
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