ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Precise and fuzzy coding by olfactory sensory neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Receptors underlying an odorant's valence across concentrations in Drosophila larvae.The Journal of experimental biology · 2024Article
- Depolarization block in olfactory sensory neurons expands the dimensionality of odor encoding.Science advances · 2022Article
- A GAL80 Collection To Inhibit GAL4 Transgenes inG3 (Bethesda, Md.) · 2018Article
- Prior activity of olfactory receptor neurons is required for proper sensory processing and behavior in Drosophila larvae.Scientific reports · 2018Article
- The Two Main Olfactory Receptor Families inFrontiers in cellular neuroscience · 2018Review
- A Background of a Volatile Plant Compound Alters Neural and Behavioral Responses to the Sex Pheromone Blend in a Moth.Frontiers in physiology · 2017Article
- The peripheral olfactory code in Drosophila larvae contains temporal information and is robust over multiple timescales.Proceedings. Biological sciences · 2016Article
- Article
- The neuro-ecology of Drosophila pupation behavior.PloS one · 2014Article
- Parallel processing via a dual olfactory pathway in the honeybee.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Embryonic origin of olfactory circuitry in Drosophila: contact and activity-mediated interactions pattern connectivity in the antennal lobe.PLoS biology · 2012Article
- Modeling peripheral olfactory coding in Drosophila larvae.PloS one · 2011Article
- Mechanisms of odor-tracking: multiple sensors for enhanced perception and behavior.Frontiers in cellular neuroscience · 2010Article
- A circuit supporting concentration-invariant odor perception in Drosophila.Journal of biology · 2009Article
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3 authors.
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Abstract
The exact nature of the olfactory signals that arrive in the brain from the periphery, and their reproducibility, remain essentially unknown. In most organisms, the sheer number of olfactory sensory neurons (OSNs) makes it impossible to measure the individual responses of the entire population. We measured the individual in situ electrophysiological activity of OSNs in Drosophila larvae, in response to stimulation with 10 aliphatic odors (alcohols and esters). We studied control larvae (a total of 296 OSNs) and larvae with a single functional OSN, created using the Gal4-upstream activator sequence system. Most OSNs showed consistent, precise responses (either excitation or inhibition) in response to a given odor. Some OSNs also showed qualitatively variable responses ("fuzzy coding"). This robust variability was an intrinsic property of these neurons: it was not attributable to odor type, concentration, stimulus duration, genotype, or interindividual differences, and was seen in control larvae and in larvae with one and two functional OSNs. We conclude that in Drosophila larvae the peripheral code combines precise coding with fuzzy, stochastic responses in which neurons show qualitative variability in their responses to a given odor. We hypothesize that fuzzy coding occurs in other organisms, is translated into differing degrees of activation of the glomeruli, and forms a key component of response variability in the first stages of olfactory processing.
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