ArticleAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2008
Prenatal exposure to acetaminophen and respiratory symptoms in the first year of life.
Article in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- Long-Term Safety of Prenatal and Neonatal Exposure to Paracetamol: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- [Pediatric perioperative systemic pain therapy: Austrian interdisciplinary recommendations on pediatric perioperative pain management].Schmerz (Berlin, Germany) · 2014Guideline
- Developmentally Regulated CYP2E1 Expression Is Associated with a Fetal Pulmonary Transcriptional Response to Maternal Acetaminophen Exposure.Biomedicines · 2025Article
- A Single Early-Life Acetaminophen Exposure Causes Persistent Abnormalities in the Murine Lung.American journal of respiratory cell and molecular biology · 2025Article
- Racing against time: leveraging preclinical models to understand pulmonary susceptibility to perinatal acetaminophen exposures.American journal of physiology. Lung cellular and molecular physiology · 2022Review
- Prenatal Exposure to Acetaminophen and Childhood Asthmatic Symptoms in a Population-Based Cohort in Los Angeles, California.International journal of environmental research and public health · 2021Article
- Acetaminophen and the Developing Lung: Could There Be Lifelong Consequences?The Journal of pediatrics · 2021Review
- Comparison of fetal growth by maternal prenatal acetaminophen use.Pediatric research · 2019Article
- PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses.Pharmacogenetics and genomics · 2015Article
- Perinatal paracetamol exposure in mice does not affect the development of allergic airways disease in early life.Thorax · 2015Article
- Relationship between prenatal antibiotic use and asthma in at-risk children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2015Article
- Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children.The Journal of allergy and clinical immunology · 2015Article
- Article
- Effects of ibuprofen, diclofenac, naproxen, and piroxicam on the course of pregnancy and pregnancy outcome: a prospective cohort study.BJOG : an international journal of obstetrics and gynaecology · 2013Article
- Prenatal and perinatal analgesic exposure and autism: an ecological link.Environmental health : a global access science source · 2013Article
- Effects of Acetaminophen consumption in asthmatic children.Iranian Red Crescent medical journal · 2012Article
- Human teratogens update 2011: can we ensure safety during pregnancy?Birth defects research. Part A, Clinical and molecular teratology · 2012Review
- Use of prescription paracetamol during pregnancy and risk of asthma in children: a population-based Danish cohort study.Clinical epidemiology · 2012Article
- Effect of prenatal exposure to fine particulate matter and intake of Paracetamol (Acetaminophen) in pregnancy on eczema occurrence in early childhood.The Science of the total environment · 2011Article
- The role of acetaminophen and geohelminth infection on the incidence of wheeze and eczema: a longitudinal birth-cohort study.American journal of respiratory and critical care medicine · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPrevalence of asthma in developed countries increased between the 1970s and the 1990s. One factor that might contribute to the trends in asthma is the increased use of acetaminophen vs aspirin in children and pregnant women.
objectiveTo examine relationships between in utero exposure to acetaminophen and incidence of respiratory symptoms in the first year of life.
methodsA total of 345 women were recruited in the first trimester of pregnancy and followed up with their children through the first year of life. Use of acetaminophen in pregnancy was determined by questionnaire and related to incidence of respiratory symptoms.
resultsUse of acetaminophen in middle to late but not early pregnancy was significantly related to wheezing (odd ratio, 1.8; 95% confidence interval, 1.1-3.0) and to wheezing that disturbed sleep (odds ratio, 2.1; 95% confidence interval, 1.1-3.8) in the first year of life after control for potential confounders.
conclusionThis study suggests that use of acetaminophen in middle to late but not early pregnancy may be related to respiratory symptoms in the first year of life. Additional follow-up will examine relationships of maternal and early childhood use of acetaminophen with incidence of asthma at ages 3 to 5 years, when asthma diagnosis is more firmly established.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.