ArticleDevelopmental neurobiology2008
Functional differentiation of a clone resembling embryonic cortical interneuron progenitors.
Article in Developmental neurobiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Dicer1 Ablation Impairs Responsiveness of Cerebellar Granule Neuron Precursors to Sonic Hedgehog and Disrupts Expression of Distinct Cell Cycle Regulator Genes.Cerebellum (London, England) · 2017Article
- Cornu Ammonis Regions-Antecedents of Cortical Layers?Frontiers in neuroanatomy · 2017Review
- An enhanced role and expanded developmental origins for gamma-aminobutyric acidergic interneurons in the human cerebral cortex.Journal of anatomy · 2015Review
- The early fetal development of human neocortical GABAergic interneurons.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- A positive feedback mechanism that regulates expression of miR-9 during neurogenesis.PloS one · 2014Article
- Production and organization of neocortical interneurons.Frontiers in cellular neuroscience · 2013Review
- Isolation of a novel rat neural progenitor clone that expresses Dlx family transcription factors and gives rise to functional GABAergic neurons in culture.Developmental neurobiology · 2012Article
- Clonal production and organization of inhibitory interneurons in the neocortex.Science (New York, N.Y.) · 2011Article
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Authors and funding
12 authors at 1 institution in 1 country.
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Abstract
We have generated clones (L2.3 and RG3.6) of neural progenitors with radial glial properties from rat E14.5 cortex that differentiate into astrocytes, neurons, and oligodendrocytes. Here, we describe a different clone (L2.2) that gives rise exclusively to neurons, but not to glia. Neuronal differentiation of L2.2 cells was inhibited by bone morphogenic protein 2 (BMP2) and enhanced by Sonic Hedgehog (SHH) similar to cortical interneuron progenitors. Compared with L2.3, differentiating L2.2 cells expressed significantly higher levels of mRNAs for glutamate decarboxylases (GADs), DLX transcription factors, calretinin, calbindin, neuropeptide Y (NPY), and somatostatin. Increased levels of DLX-2, GADs, and calretinin proteins were confirmed upon differentiation. L2.2 cells differentiated into neurons that fired action potentials in vitro, and their electrophysiological differentiation was accelerated and more complete when cocultured with developing astroglial cells but not with conditioned medium from these cells. The combined results suggest that clone L2.2 resembles GABAergic interneuron progenitors in the developing forebrain.
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