ArticleDevelopment genes and evolution2008
Evolution of DNA-methylation machinery: DNA methyltransferases and methyl-DNA binding proteins in the amphioxus Branchiostoma floridae.
Article in Development genes and evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Hydra at the Crossroads of Evolution: Insights into Cell-type Diversification, Regeneration, and Epigenetic Regulation.Results and problems in cell differentiation · 2026Review
- Whole organism integrated DNA methylation and transcriptomics analysis of butterfly metamorphosis.Scientific reports · 2025Article
- Genome-wide DNA methylation patterns in Daphnia magna are not significantly associated with age.Epigenetics & chromatin · 2025Article
- A Broad Survey of Gene Body and Repeat Methylation in Cnidaria Reveals a Complex Evolutionary History.Genome biology and evolution · 2022Article
- The emergence of the brain non-CpG methylation system in vertebrates.Nature ecology & evolution · 2021Article
- The Methyl-CpG-Binding Domain 2 and 3 Proteins and Formation of the Nucleosome Remodeling and Deacetylase Complex.Journal of molecular biology · 2020Review
- Evolutionary history of DNA methylation related genes in chordates: new insights from multiple whole genome duplications.Scientific reports · 2020Article
- Universality of the DNA methylation codes in Eucaryotes.Scientific reports · 2019Article
- Wnt evolution and function shuffling in liberal and conservative chordate genomes.Genome biology · 2018Article
- Methylation specific targeting of a chromatin remodeling complex from sponges to humans.Scientific reports · 2017Article
- Evolution by gene loss.Nature reviews. Genetics · 2016Review
- DNA Methylation in Basal Metazoans: Insights from Ctenophores.Integrative and comparative biology · 2015Review
- CpG dinucleotide frequencies reveal the role of host methylation capabilities in parvovirus evolution.Journal of virology · 2013Article
- Planarian MBD2/3 is required for adult stem cell pluripotency independently of DNA methylation.Developmental biology · 2013Article
- Solution structure and dynamic analysis of chicken MBD2 methyl binding domain bound to a target-methylated DNA sequence.Nucleic acids research · 2011Article
- Apoptosis and DNA methylation.Cancers · 2011Article
- The amphioxus genome sequence illuminates the evolutionary origin of vertebrates.Development genes and evolution · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation is an epigenetic mark associated with gene regulation and cell memory, silencing of transposable elements, genomic imprinting, and repression of spurious transcription of duplicated sequences. These roles have varied widely during animal evolution and current functions depend on the specific methylation pattern of the species under consideration. The patterns of methylation are established, maintained, and translated into appropriate functional states by the DNA-methylation machinery, which includes three groups of methyltransferase enzymes, Dnmt1, Dnmt2 and Dnmt3, and five methyl-DNA binding proteins, Mbd1, Mbd2, Mbd3, Mbd4, and MeCP2. In this study, I have identified the members of the Dnmt and the Mbd gene families in the cephalochordate amphioxus (Branchiostoma floridae), the most basal extant chordate and one of the closest sister groups of vertebrates. Database searches, phylogenetic studies and protein domain analyses revealed the presence of the three major groups of Dnmt enzymes in the cephalochordate genome, whereas only two Mbd members, Mbd2/3 and Mbd4, were found. Analysis of the amphioxus methylation machinery suggested that the complexity and the structural organization of cephalochordate methyltransferases do not differ substantially from those of current vertebrate enzymes, while new Mbd proteins arose in vertebrates, which perhaps minimized certain collateral effects associated with the major genomic changes that occurred during the invertebrate-vertebrate transition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.