ArticleNeoplasia (New York, N.Y.)2008
Integrated nanosensors to determine levels and functional activity of human telomerase.
Article in Neoplasia (New York, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
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- Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy.Accounts of chemical research · 2011Review
- The assembly state between magnetic nanosensors and their targets orchestrates their magnetic relaxation response.Journal of the American Chemical Society · 2011Article
- Identification of molecular-mimicry-based ligands for cholera diagnostics using magnetic relaxation.Bioconjugate chemistry · 2011Article
- Dinosaurs and ancient civilizations: reflections on the treatment of cancer.Neoplasia (New York, N.Y.) · 2010Article
- TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression.Neoplasia (New York, N.Y.) · 2010Article
- Emerging nanotechnology-based strategies for the identification of microbial pathogenesis.Advanced drug delivery reviews · 2010Review
- Magnetic nanoparticles for biomedical NMR-based diagnostics.Beilstein journal of nanotechnology · 2010Article
- Functionalization of iron oxide nanoparticles with a versatile epoxy amine linker.Journal of materials chemistry · 2010Article
- The War on Cancer rages on.Neoplasia (New York, N.Y.) · 2009Article
- Role of nanoparticle valency in the nondestructive magnetic-relaxation-mediated detection and magnetic isolation of cells in complex media.Journal of the American Chemical Society · 2009Article
- Neoplasia: the second decade.Neoplasia (New York, N.Y.) · 2008Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Telomerase is a key oncogenic enzyme, and a number of novel telomerase inhibitors are currently under development. Because inhibition can be achieved either at the protein or at the enzymatic activity level, independent measurements of these parameters are important in the development of effective therapeutic agents. In the current study, we have developed a set of functional magnetic nanosensors capable of measuring the concentration of telomerase, as well as its enzymatic activity in parallel. The method is based on a magnetic relaxation switch assay, which can be performed in crude tissue samples and is fast and extremely sensitive. Using this method, we were able to detect different amounts of telomerase protein and activity in various cancer and normal cell lines. Furthermore, we were able to study the effect of phosphorylation on telomerase activity. This system not only could provide a rapid assay for the evaluation of antitelomerase therapies but could also be implemented to the study of other cancer markers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.