ArticleProceedings of the National Academy of Sciences of the United States of America2008
The genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium important in the marine nitrogen cycle.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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88 citing papers in PubMed, 168 citations in OpenAlex.
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- Modeling dynamic oxygen permeability as a mechanism to mitigate oxygen-induced stresses on photosynthesis and NMicrobiology spectrum · 2025Article
- Kinetic and homology model analysis of diaminopimelate decarboxylase from Cyanothece sp. ATCC 51142: unveiling a key enzyme in lysine biosynthesis.Bioscience reports · 2025Article
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- Proteomic changes orchestrate metabolic acclimation of a unicellular diazotrophic cyanobacterium during light-dark cycle and nitrogen fixation states.bioRxiv : the preprint server for biology · 2024Article
- Proteomic analysis of unicellular cyanobacteriumbioRxiv : the preprint server for biology · 2024Article
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- Heterotrophy among Cyanobacteria.ACS omega · 2023Review
- Chemoproteomic Approaches for Unraveling Prokaryotic Biology.Israel journal of chemistry · 2023Article
- Introduction to Cyanobacteria.Advances in biochemical engineering/biotechnology · 2023Article
- A novel salt- and organic solvent-tolerant phosphite dehydrogenase fromFrontiers in bioengineering and biotechnology · 2023Article
- Diurnally dynamic iron allocation promotes NComputational and structural biotechnology journal · 2023Article
- Photosynthetic modulation during the diurnal cycle in a unicellular diazotrophic cyanobacterium grown under nitrogen-replete and nitrogen-fixing conditions.Scientific reports · 2022Article
- The Beneficial Effects of Cyanobacterial Co-Culture on Plant Growth.Life (Basel, Switzerland) · 2022Review
- Bioactive substances and potentiality of marine microalgae.Food science & nutrition · 2021Review
- Genetic, Genomics, and Responses to Stresses in Cyanobacteria: Biotechnological Implications.Genes · 2021Review
28 more citing papers are in PubMed but not listed here.
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16 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Unicellular cyanobacteria have recently been recognized for their contributions to nitrogen fixation in marine environments, a function previously thought to be filled mainly by filamentous cyanobacteria such as Trichodesmium. To begin a systems level analysis of the physiology of the unicellular N(2)-fixing microbes, we have sequenced to completion the genome of Cyanothece sp. ATCC 51142, the first such organism. Cyanothece 51142 performs oxygenic photosynthesis and nitrogen fixation, separating these two incompatible processes temporally within the same cell, while concomitantly accumulating metabolic products in inclusion bodies that are later mobilized as part of a robust diurnal cycle. The 5,460,377-bp Cyanothece 51142 genome has a unique arrangement of one large circular chromosome, four small plasmids, and one linear chromosome, the first report of a linear element in the genome of a photosynthetic bacterium. On the 429,701-bp linear chromosome is a cluster of genes for enzymes involved in pyruvate metabolism, suggesting an important role for the linear chromosome in fermentative processes. The annotation of the genome was significantly aided by simultaneous global proteomic studies of this organism. Compared with other nitrogen-fixing cyanobacteria, Cyanothece 51142 contains the largest intact contiguous cluster of nitrogen fixation-related genes. We discuss the implications of such an organization on the regulation of nitrogen fixation. The genome sequence provides important information regarding the ability of Cyanothece 51142 to accomplish metabolic compartmentalization and energy storage, as well as how a unicellular bacterium balances multiple, often incompatible, processes in a single cell.
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