ArticleProceedings of the National Academy of Sciences of the United States of America2008
The stem rust resistance gene Rpg5 encodes a protein with nucleotide-binding-site, leucine-rich, and protein kinase domains.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 151 citations in OpenAlex.
- Meta-QTLs for multiple disease resistance involving three rusts in common wheat (Triticum aestivum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Pooled it
- Identification of adaptive selection footprints and adaptation strategies of hulless barley (Hordeum vulgare var. coeleste) on the Qinghai-Tibet Plateau.BMC genomics · 2026Article
- The emerging role of kinase fusion proteins in cereal immunity.Nature genetics · 2026Review
- Identification and association mapping of sources of stem rust resistance in the wild barley diversity panel effective against virulent isolates from the Pacific Northwest.G3 (Bethesda, Md.) · 2026Article
- Accelerating Resistance Breeding: Emerging Methods to Identify and Validate Plant Immunity Genes.Plants (Basel, Switzerland) · 2026Review
- Whole-genome resequencing of the wild barley diversity collection: a resource for identifying and exploiting genetic variation for cultivated barley improvement.G3 (Bethesda, Md.) · 2026Article
- Genome-wide association mapping of loci conferring all-stage and high-temperature adult-plant resistance to stripe rust in a global spring barley collection.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- An Aegilops longissima NLR protein with integrated CC-BED module mediates resistance to wheat powdery mildew.Nature communications · 2024Article
- A kinase fusion protein from Aegilops longissima confers resistance to wheat powdery mildew.Nature communications · 2024Article
- Association mapping with a diverse population of Puccinia graminis f. sp. tritici identified avirulence loci interacting with the barley Rpg1 stem rust resistance gene.BMC genomics · 2024Article
- Review
- Genome-wide association study of resistance to anthracnose in pepper (Capsicum chinense) germplasm.BMC plant biology · 2023Article
- Identifying Putative Resistance Genes for Barley Yellow Dwarf Virus-PAV in Wheat and Barley.Viruses · 2023Review
- Show me your ID: NLR immune receptors with integrated domains in plants.Essays in biochemistry · 2022Article
- Identification of aInternational journal of molecular sciences · 2022Article
- Barley Stripe Mosaic Virus (BSMV)-Based Virus-Induced Gene Silencing to Functionally Characterize Genes in Wheat and Barley.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Plant NLRs: Evolving with pathogen effectors and engineerable to improve resistance.Frontiers in microbiology · 2022Review
- QTL Mapping of Adult Plant Resistance to Stripe Rust in a Doubled Haploid Wheat Population.Frontiers in genetics · 2022Article
- The wheat Sr22, Sr33, Sr35 and Sr45 genes confer resistance against stem rust in barley.Plant biotechnology journal · 2021Article
- Article
Corrections and comments
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Authors and funding
17 authors at 11 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We isolated the barley stem rust resistance genes Rpg5 and rpg4 by map-based cloning. These genes are colocalized on a 70-kb genomic region that was delimited by recombination. The Rpg5 gene consists of an unusual structure encoding three typical plant disease resistance protein domains: nucleotide-binding site, leucine-rich repeat, and serine threonine protein kinase. The predicted RPG5 protein has two putative transmembrane sites possibly involved in membrane binding. The gene is expressed at low but detectable levels. Posttranscriptional gene silencing using VIGS resulted in a compatible reaction with a normally incompatible stem rust pathogen. Allele sequencing also validated the candidate Rpg5 gene. Allele and recombinant sequencing suggested that the probable rpg4 gene encoded an actin depolymerizing factor-like protein. Involvement of actin depolymerizing factor genes in nonhost resistance has been documented, but discovery of their role in gene-for-gene interaction would be novel and needs to be further substantiated.
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