ArticleThe Plant cell2008
Arabidopsis ARC6 coordinates the division machineries of the inner and outer chloroplast membranes through interaction with PDV2 in the intermembrane space.
Article in The Plant cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 131 citations in OpenAlex.
- Plant organelle division orchestrated by the mosaic machinery of endosymbiotic relics and eukaryotic host factors.Plant physiology · 2026Review
- Dual Cytoplasmic and Chloroplastic Mechanisms Fine-Tune Chloroplast Division through ARC3 Protein Stability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Simultaneous defects in chloroplast development and division cause leaf variegation in Arabidopsis.Plant communications · 2026Article
- Binary division of plastids involves endoplasmic reticulum mediation.Journal of experimental botany · 2025Article
- Enhanced chloroplast FtsZ-ring constriction by the ARC6-ARC3 module inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Auxin promotes chloroplast division by increasing the expression of chloroplast division genes.Plant cell reports · 2024Article
- AcGLK1 promotes chloroplast division through regulating AcFtsZ1 in Actinidia chinensis.Planta · 2024Article
- Structure, biogenesis, and evolution of thylakoid membranes.The Plant cell · 2024Review
- Principles of amyloplast replication in the ovule integuments of Arabidopsis thaliana.Plant physiology · 2024Article
- Increasing amyloplast size in wheat endosperm through mutation of PARC6 affects starch granule morphology.The New phytologist · 2023Article
- Characterization of thylakoid division using chloroplast dividing mutants in Arabidopsis.Photosynthesis research · 2023Article
- Mutation of CsARC6 affects fruit color and increases fruit nutrition in cucumber.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Structural and functional insights into the chloroplast division site regulators PARC6 and PDV1 in the intermembrane space.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- TheInternational journal of molecular sciences · 2022Article
- J-like protein family of Arabidopsis thaliana: the enigmatic cousins of J-domain proteins.Plant cell reports · 2022Review
- DeepLearnMOR: a deep-learning framework for fluorescence image-based classification of organelle morphology.Plant physiology · 2021Article
- Mutation of SlARC6 leads to tissue-specific defects in chloroplast development in tomato.Horticulture research · 2021Article
- A de novo transcriptome analysis revealed that photomorphogenic genes are required for carotenoid synthesis in the dark-grown carrot taproot.Molecular genetics and genomics : MGG · 2020Article
- PDV1 and PDV2 Differentially Affect Remodeling and Assembly of the Chloroplast DRP5B Ring.Plant physiology · 2020Article
- Computational identification of protein-protein interactions in model plant proteomes.Scientific reports · 2019Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chloroplasts arose from a free-living cyanobacterial endosymbiont and divide by binary fission. Division involves the assembly and constriction of the endosymbiont-derived, tubulin-like FtsZ ring on the stromal surface of the inner envelope membrane and the host-derived, dynamin-like ARC5 ring on the cytosolic surface of the outer envelope membrane. Despite the identification of many proteins required for plastid division, the factors coordinating the internal and external division machineries are unknown. Here, we provide evidence that this coordination is mediated in Arabidopsis thaliana by an interaction between ARC6, an FtsZ assembly factor spanning the inner envelope membrane, and PDV2, an ARC5 recruitment factor spanning the outer envelope membrane. ARC6 and PDV2 interact via their C-terminal domains in the intermembrane space, consistent with their in vivo topologies. ARC6 acts upstream of PDV2 to localize PDV2 (and hence ARC5) to the division site. We present a model whereby ARC6 relays information on stromal FtsZ ring positioning through PDV2 to the chloroplast surface to specify the site of ARC5 recruitment. Because orthologs of ARC6 occur in land plants, green algae, and cyanobacteria but PDV2 occurs only in land plants, the connection between ARC6 and PDV2 represents the evolution of a plant-specific adaptation to coordinate the assembly and activity of the endosymbiont- and host-derived plastid division components.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.