Trial reportThe Journal of clinical endocrinology and metabolism2008
Increases in bone mineral density in response to oral dehydroepiandrosterone replacement in older adults appear to be mediated by serum estrogens.
Trial report in The Journal of clinical endocrinology and metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00111930 (Biological Effects of DHEA in the Elderly), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Biological Effects of DHEA in the Elderly
Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- Effects of testosterone and progressive resistance exercise in healthy, highly functioning older men with low-normal testosterone levels.The Journal of clinical endocrinology and metabolism · 2013Trial
- The effect of gonadal and adrenal steroid therapy on skeletal health in adolescents and young women with anorexia nervosa.Metabolism: clinical and experimental · 2012Trial
- Oral dehydroepiandrosterone replacement in older adults: effects on central adiposity, glucose metabolism and blood lipids.Clinical endocrinology · 2011Trial
- Impact of DHEA supplementation on testosterone and estradiol levels in postmenopausal women: a meta-analysis of randomized controlled trials assessing dose and duration effects.Diabetology & metabolic syndrome · 2025Review
- Association between egg consumption and major and minor ischemia changes on electrocardiogram: A population-based study.ARYA atherosclerosis · 2025Article
- Dehydroepiandrosterone and Bone Health: Mechanisms and Insights.Biomedicines · 2024Review
- Hypopituitarism and bone disease: pathophysiology, diagnosis and treatment outcomes.Pituitary · 2024Review
- Should Dehydroepiandrosterone Be Administered to Women?The Journal of clinical endocrinology and metabolism · 2022Review
- Effects of steroid hormones on lipid metabolism in sexual dimorphism: A Mendelian randomization study.Frontiers in endocrinology · 2022Article
- Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications.Mayo Clinic proceedings · 2021Review
- Appendicular lean mass is lower in late compared with early perimenopausal women: potential role of FSH.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Bone Health in the Transgender Population.Clinical reviews in bone and mineral metabolism · 2019Article
- Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials.Clinical endocrinology · 2019Article
- MR-10 Enhances Men's Health by Improving Endogenous Male Sex Hormone Generation.Journal of medicinal food · 2018Article
- The Association between Dehydroepiandrosterone Sulfate (DHEA-S) and Bone Mineral Density in Korean Men and Women.Journal of bone metabolism · 2017Article
- Sex steroid actions in male bone.Endocrine reviews · 2014Review
- Off-label use of hormones as an antiaging strategy: a review.Clinical interventions in aging · 2014Review
- A review of age-related dehydroepiandrosterone decline and its association with well-known geriatric syndromes: is treatment beneficial?Rejuvenation research · 2013Review
- Bone age advancement in prepubertal children with obesity and premature adrenarche: possible potentiating factors.Obesity (Silver Spring, Md.) · 2011Article
- Circulating dehydroepiandrosterone sulfate concentrations during the menopausal transition.The Journal of clinical endocrinology and metabolism · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
contextThe mechanisms by which dehydroepiandrosterone (DHEA) replacement increases bone mineral density (BMD) in older adults are not known.
objectiveThe aims were to determine the effects of DHEA therapy on changes in sex hormones and IGF-I and their associations with changes in BMD. DESIGN, SETTING, AND
participantsA randomized, double-blinded, placebo-controlled trial was conducted at an academic research institution. Participants were 58 women and 61 men, aged 60-88 yr, with low serum DHEA sulfate (DHEAS) levels.
interventionThe intervention was oral DHEA 50 mg/d or placebo for 12 months.
main outcome measuresBMD and serum DHEAS, testosterone, estradiol (E(2)), estrone (E(1)), SHBG, IGF-I, and IGF binding protein 3 were measured before and after intervention. Free testosterone and estrogen (FEI) indices were calculated.
resultsThe average changes in hip and spine BMD (DHEA vs. placebo) ranged from 1.1 to 1.6%. Compared with placebo, DHEA replacement increased serum DHEAS, testosterone, free testosterone index, E(1), E(2), FEI, and IGF-I (all P < 0.001) and decreased SHBG (P = 0.02) in women and, in men, increased DHEAS, E(1), FEI (all P < 0.001), and E(2) (P = 0.02) and decreased SHBG (P = 0.037). The changes in total and regional hip BMD were associated with 12-month E(2) (all P <or= 0.001) and FEI (all P <or= 0.013). The effects of DHEA treatment were eliminated by adjustment for 12-month E(2).
conclusionsThe significant increases in hip BMD in older adults undergoing DHEA replacement were mediated primarily by increases in serum E(2) rather than direct effects of DHEAS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.